ArticleNetwork neuroscience (Cambridge, Mass.)2020
In silico exploration of mouse brain dynamics by focal stimulation reflects the organization of functional networks and sensory processing.
Article in Network neuroscience (Cambridge, Mass.), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed.
- Modeling the influences of non-local connectomic projections on geometrically constrained cortical dynamics.PLoS computational biology · 2026Article
- Precision non-invasive brain stimulation: anJournal of neural engineering · 2025Article
- Stimulation mapping and whole-brain modeling reveal gradients of excitability and recurrence in cortical networks.Nature communications · 2025Article
- Analyzing the brain's dynamic response to targeted stimulation using generative modeling.Network neuroscience (Cambridge, Mass.) · 2025Review
- Article
- Strength-dependent perturbation of whole-brain model working in different regimes reveals the role of fluctuations in brain dynamics.PLoS computational biology · 2022Article
- A comprehensive neural simulation of slow-wave sleep and highly responsive wakefulness dynamics.Frontiers in computational neuroscience · 2022Article
- Robustness of connectome harmonics to local gray matter and long-range white matter connectivity changes.NeuroImage · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Resting-state functional networks such as the default mode network (DMN) dominate spontaneous brain dynamics. To date, the mechanisms linking brain structure and brain dynamics and functions in cognition, perception, and action remain unknown, mainly due to the uncontrolled and erratic nature of the resting state. Here we used a stimulation paradigm to probe the brain's resting behavior, providing insights on state-space stability and multiplicity of network trajectories after stimulation. We performed explorations on a mouse model to map spatiotemporal brain dynamics as a function of the stimulation site. We demonstrated the emergence of known functional networks in brain responses. Several responses heavily relied on the DMN and were suggestive of the DMN playing a mechanistic role between functional networks. We probed the simulated brain responses to the stimulation of regions along the information processing chains of sensory systems from periphery up to primary sensory cortices. Moreover, we compared simulated dynamics against in vivo brain responses to optogenetic stimulation. Our results underwrite the importance of anatomical connectivity in the functional organization of brain networks and demonstrate how functionally differentiated information processing chains arise from the same system.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.