ArticleNetwork neuroscience (Cambridge, Mass.)2020
Timescales of spontaneous fMRI fluctuations relate to structural connectivity in the brain.
Article in Network neuroscience (Cambridge, Mass.), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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42 citing papers in PubMed, 67 citations in OpenAlex.
- Priming cardiovascular exercise improves complex motor skill learning by affecting the trajectory of learning-related brain plasticity.Scientific reports · 2022Trial
- Thalamic modulation of cortical linearity across arousal states.Science advances · 2026Article
- Neural timescales from a computational perspective.Nature neuroscience · 2026Review
- Longitudinal Multimodal Neuroimaging After Traumatic Brain Injury.Human brain mapping · 2026Article
- Selective control of prefrontal neural timescales by parietal cortex.Nature communications · 2026Article
- Temporal and Spatial Scales of Human Resting-State Cortical Activity across the Lifespan.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Inferring intrinsic neural timescales using optimal control theory.Nature communications · 2025Article
- Spectral imprint of structural embedding in effective connectivity.bioRxiv : the preprint server for biology · 2025Article
- Conserved brain-wide emergence of emotional response from sensory experience in humans and mice.Science (New York, N.Y.) · 2025Article
- Sleep Modulates Neural Timescales and Spatiotemporal Integration in the Human Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Network Mechanisms Underlying the Regional Diversity of Variance and Time Scales of the Brain's Spontaneous Activity Fluctuations.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Structurally informed models of directed brain connectivity.Nature reviews. Neuroscience · 2025Review
- Behavioural stochastic resonance across the lifespan.Cognitive, affective & behavioral neuroscience · 2024Article
- A network control theory pipeline for studying the dynamics of the structural connectome.Nature protocols · 2024Article
- Extracting interpretable signatures of whole-brain dynamics through systematic comparison.PLoS computational biology · 2024Article
- Extracting interpretable signatures of whole-brain dynamics through systematic comparison.bioRxiv : the preprint server for biology · 2024Article
- The significance of structural rich club hubs for the processing of hierarchical stimuli.Human brain mapping · 2024Article
- Cortical timescales and the modular organization of structural and functional brain networks.Human brain mapping · 2024Article
- Dendrites contribute to the gradient of intrinsic timescales encompassing cortical and subcortical brain networks.Frontiers in cellular neuroscience · 2024Article
- Towards a biologically annotated brain connectome.Nature reviews. Neuroscience · 2023Review
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Intrinsic timescales of activity fluctuations vary hierarchically across the brain. This variation reflects a broad gradient of functional specialization in information storage and processing, with integrative association areas displaying slower timescales that are thought to reflect longer temporal processing windows. The organization of timescales is associated with cognitive function, distinctive between individuals, and disrupted in disease, but we do not yet understand how the temporal properties of activity dynamics are shaped by the brain's underlying structural connectivity network. Using resting-state fMRI and diffusion MRI data from 100 healthy individuals from the Human Connectome Project, here we show that the timescale of resting-state fMRI dynamics increases with structural connectivity strength, matching recent results in the mouse brain. Our results hold at the level of individuals, are robust to parcellation schemes, and are conserved across a range of different timescale- related statistics. We establish a comprehensive BOLD dynamical signature of structural connectivity strength by comparing over 6,000 time series features, highlighting a range of new temporal features for characterizing BOLD dynamics, including measures of stationarity and symbolic motif frequencies. Our findings indicate a conserved property of mouse and human brain organization in which a brain region's spontaneous activity fluctuations are closely related to their surrounding structural scaffold.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.