Evidence map›Paper›PMID 33615069›Full record

ArticleKidney international reports2021

Adherence to the Kidney Disease: Improving Global Outcomes CKD Guideline in Nephrology Practice Across Countries.

Bénédicte Stengel, Daniel Muenz, Charlotte Tu, Elodie Speyer, Natalia Alencar de Pinho, Christian Combe, Kunihiro Yamagata, Helmut Reichel, Danilo Fliser, Ziad A Massy and 7 more

Registry-linked trialAbstract read
In one paragraph

Article in Kidney international reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03381950 (Chronic Kidney Disease - Renal Epidemiology and Information Network), which is not on this map. Cited by 45 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03381950 completednot on this map

Chronic Kidney Disease - Renal Epidemiology and Information Network: The CKD-REIN Cohort

TypeobservationalSponsorInstitut National de la Santé Et de la Recherche Médicale, FranceRan2013 to 2020Enrolled3,033ConditionsRenal Insufficiency, Chronic
3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Guideline
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Addressing Unmet Needs in the Management of Chronic Kidney Disease.International journal of general medicine · 2026
    Review
  12. Cardio-kidney-metabolic (CKM) framework: A nephrologist's perspective.Archives of endocrinology and metabolism · 2025
    Review
  13. Review
  14. Urinary L-FABP: A Novel Biomarker for Evaluating Diabetic Nephropathy Onset and Progression. A Narrative Review.Diabetes therapy : research, treatment and education of diabetes and related disorders · 2025
    Review
  15. Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

17 authors.

Bénédicte StengelCentre for Research in Epidemiology and Population Health, Paris-Saclay University, Versailles Saint Quentin University, INSERM UMRS 1018, Villejuif, France.
Daniel MuenzArbor Research Collaborative for Health, Ann Arbor, Michigan, USA.
Charlotte TuArbor Research Collaborative for Health, Ann Arbor, Michigan, USA.
Elodie SpeyerCentre for Research in Epidemiology and Population Health, Paris-Saclay University, Versailles Saint Quentin University, INSERM UMRS 1018, Villejuif, France.
Natalia Alencar de PinhoCentre for Research in Epidemiology and Population Health, Paris-Saclay University, Versailles Saint Quentin University, INSERM UMRS 1018, Villejuif, France.
Christian CombeService de Néphrologie Transplantation Dialyse Aphérèse, Centre Hospitalier Universitaire de Bordeaux, Bordeaux, France.
Kunihiro YamagataDepartment of Nephrology, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan.
Helmut ReichelNephrological Center, Villingen-Schwenningen, Germany.
Danilo FliserDepartment of Internal Medicine IV, Saarland University Medical Center, Homburg, Germany.
Ziad A MassyCentre for Research in Epidemiology and Population Health, Paris-Saclay University, Versailles Saint Quentin University, INSERM UMRS 1018, Villejuif, France.
Antonio A LopesDepartment of Internal Medicine, Federal University of Bahia, Salvador, Brazil.
Michel JadoulDepartment of Nephrology, Cliniques Universitaires Saint-Luc, Université Catholique de Louvain, Brussels, Belgium.
Wolfgang C WinkelmayerSection for Nephrology and Selzman Institute for Kidney Health, Baylor College of Medicine, Houston, Texas, USA.
Ronald L PisoniArbor Research Collaborative for Health, Ann Arbor, Michigan, USA.
Bruce M RobinsonArbor Research Collaborative for Health, Ann Arbor, Michigan, USA.
Roberto Pecoits-FilhoArbor Research Collaborative for Health, Ann Arbor, Michigan, USA.
CKDopps investigators

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThe uptake of the Kidney Disease: Improving Global Outcomes (KDIGO) 2012 chronic kidney disease (CKD) Guideline is not fully described in real-world nephrology practice across the world.

methodsWe used baseline data from the CKD Outcomes and Practice Patterns Study (2013-2017), a 4-country cohort of patients with estimated glomerular filtration rate <60 ml/min per 1.73 m

resultsThe mean age ranged from 65 years in Brazil to 72 years in Germany. Albuminuria (mostly proteinuria) was measured routinely in 36% to 43% of patients in Brazil, Germany, and the United States. Blood pressure control (≤140/90 mm Hg) ranged from 49% in France to 76% in Brazil; <40% of patients had blood pressure ≤130/80 mm Hg everywhere but Brazil (52%). More than 40% of nephrologists in Brazil reported a systolic blood pressure target ≤130 mm Hg for nondiabetic patients without proteinuria, but only 19% to 24% elsewhere. Prescription of renin-angiotensin aldosterone system inhibitors ranged from 52% in the United States to 81% in Germany. Dietary advice was more frequent for salt than protein intake; dietitian visits were uncommon. In nondiabetic patients, achievement of all 3 targets including blood pressure ≤130/80 mm Hg, renin-angiotensin aldosterone system inhibition, and dietary advice, ranged from 10% in the United States to 32% in Brazil; in treated diabetic patients, this ranged from 6% to 11% after including hemoglobin A1c target.

conclusionAdherence to recommendations to slow CKD progression is low in typical practice settings, and substantial variation among countries for some indicates opportunities for improvement.

Indexed as

albuminuriablood pressure controlchronic kidney diseasedietary advicelifestylerenin-angiotensin system inhibition

Identifiers

PMID33615069
PMCPMC7879121

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.