ReviewFrontiers in cardiovascular medicine2021
Arrhythmogenic Mechanisms in Hypokalaemia: Insights From Pre-clinical Models.
Review in Frontiers in cardiovascular medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 24 citations in OpenAlex.
- Paroxysmal Atrial Tachycardia With Atrioventricular Block: A Report of Two Cases.Case reports in medicine · 2026Article
- Prevalence of electrocardiographic abnormalities and predictors of QTc prolongation in patients with diabetic ketoacidosis: A retrospective cohort study.SAGE open medicine · 2026Article
- The effect of clinically relevant changes in extracellular electrolyte concentrations on human atrial arrhythmias.Communications medicine · 2025Article
- Changes of b2-microglobulin and electrolytes in different stages of COPD and their value in evaluating prognosis.Journal of medical biochemistry · 2024Article
- Rapid changes of mRNA expressions of cardiac ion channels affected by Torsadogenic drugs influence susceptibility of rat hearts to arrhythmias induced by Beta-Adrenergic stimulation.Pharmacology research & perspectives · 2023Article
- Cardiac arrhythmias in primary hypokalemic periodic paralysis: Case report and literature review.HeartRhythm case reports · 2022Article
- Article
- Mechanistic Insights Into Inflammation-Induced Arrhythmias: A Simulation Study.Frontiers in physiology · 2022Article
- Severe Tachycardia Associated with Psychotropic Medications in Psychiatric Inpatients: A Study of Hospital Medical Emergency Team Activation.Journal of clinical medicine · 2021Article
- Arrhythmic Risk Assessment of Hypokalaemia Using Human Pluripotent Stem Cell-Derived Cardiac Anisotropic Sheets.Frontiers in cell and developmental biology · 2021Article
- Measures of repolarization variability predict ventricular arrhythmogenesis in heptanol-treated Langendorff-perfused mouse hearts.Current research in physiology · 2021Article
Corrections and comments
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Authors and funding
13 authors at 12 institutions in 5 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Potassium is the predominant intracellular cation, with its extracellular concentrations maintained between 3. 5 and 5 mM. Among the different potassium disorders, hypokalaemia is a common clinical condition that increases the risk of life-threatening ventricular arrhythmias. This review aims to consolidate pre-clinical findings on the electrophysiological mechanisms underlying hypokalaemia-induced arrhythmogenicity. Both triggers and substrates are required for the induction and maintenance of ventricular arrhythmias. Triggered activity can arise from either early afterdepolarizations (EADs) or delayed afterdepolarizations (DADs). Action potential duration (APD) prolongation can predispose to EADs, whereas intracellular Ca
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.