ArticleFrontiers in cell and developmental biology2021
Effect of Physical Training on Exercise-Induced Inflammation and Performance in Mice.
Article in Frontiers in cell and developmental biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 26 citations in OpenAlex.
- Modeling the Exposome in Murine Cardiovascular Disease.JACC. Basic to translational science · 2026Review
- Transcriptomic signatures reveal systemic adaptations and immune modulation in response to training and competitive racing in horses.Equine veterinary journal · 2026Article
- Anti-Fatigue Effects of Donkey Milk and Its Polysaccharides in a Mouse Swimming Model.Foods (Basel, Switzerland) · 2026Article
- Ginsenoside Rg1 enhances stem cell abundance in aging human skeletal muscle after resistance exercise.Journal of ginseng research · 2026Article
- Adaptations in mitochondrial quality control and interactions with innate immune signaling within skeletal muscle: A narrative review.Journal of sport and health science · 2025Review
- Moderate Highland Barley Intake Affects Anti-Fatigue Capacity in Mice via Metabolism, Anti-Oxidative Effects and Gut Microbiota.Nutrients · 2025Article
- Effects and mechanisms of polysaccharides from natural medicinal plants on improving aerobic exercise capacity.Frontiers in nutrition · 2025Review
- Exercise interventions for pulmonary function impairment: rehabilitation strategies from the acute phase to long-term sequelae.Frontiers in physiology · 2025Review
- Matrikines of Sea Cucumbers: Structure, Biological Activity and Mechanisms of Action.International journal of molecular sciences · 2024Review
- Over Activation of IL-6/STAT3 Signaling Pathway in Juvenile Dermatomyositis.Rheumatology and therapy · 2024Article
- Chronic supplementation of noni in diabetic type 1-STZ rats: effects on glycemic levels, kidney toxicity and exercise performance.Diabetology & metabolic syndrome · 2023Article
- Comparison of preventive and therapeutic effects of continuous exercise on acute lung injury induced with methotrexate.Experimental physiology · 2023Article
- Dietary Polysaccharides Exert Anti-Fatigue Functions via the Gut-Muscle Axis: Advances and Prospectives.Foods (Basel, Switzerland) · 2023Review
- Signaling pathways regulated by natural active ingredients in the fight against exercise fatigue-a review.Frontiers in pharmacology · 2023Review
- Immune remodeling and atrial fibrillation.Frontiers in physiology · 2022Review
- The use of traditional Chinese medicines in relieving exercise-induced fatigue.Frontiers in pharmacology · 2022Review
Corrections and comments
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Authors and funding
12 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Acute exercise increases the amount of circulating inflammatory cells and cytokines to maintain physiological homeostasis. However, it remains unclear how physical training regulates exercise-induced inflammation and performance. Here, we demonstrate that acute high intensity exercise promotes an inflammatory profile characterized by increased blood IL-6 levels, neutrophil migratory capacity, and leukocyte recruitment to skeletal muscle vessels. Moreover, we found that physical training amplified leukocyte-endothelial cell interaction induced by acute exercise in skeletal muscle vessels and diminished exercise-induced inflammation in skeletal muscle tissue. Furthermore, we verified that disruption of the gp-91 subunit of NADPH-oxidase inhibited exercise-induced leukocyte recruitment on skeletal muscle after training with enhanced exercise time until fatigue. In conclusion, the training was related to physical improvement and immune adaptations. Moreover, reactive oxygen species (ROS) could be related to mechanisms to limit aerobic performance and its absence decreases the inflammatory response elicited by exercise after training.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.