Evidence map›Paper›PMID 33614635›Full record

ArticleFrontiers in cell and developmental biology2020

Structural and Functional Dysbiosis of Fecal Microbiota in Chinese Patients With Alzheimer's Disease.

Zongxin Ling, Manlian Zhu, Xiumei Yan, Yiwen Cheng, Li Shao, Xia Liu, Ruilai Jiang, Shaochang Wu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cell and developmental biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 154 papers, 11 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
154citing papers in PubMed, 11 pooled it
11.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

154 citing papers in PubMed, 11 syntheses or guidelines pooled it, 226 citations in OpenAlex.

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  2. Global Microbiome: Core and Unique Signatures Across Diverse Populations.International journal of molecular sciences · 2026
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  20. Biomolecules · 2026
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94 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 1 country.

Zongxin LingState Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, School of Medicine, The First Affiliated Hospital, Zhejiang University, Hangzhou, China.
Manlian ZhuDepartment of Geriatrics, Lishui Second People's Hospital, Lishui, China.
Xiumei YanDepartment of Geriatrics, Lishui Second People's Hospital, Lishui, China.
Yiwen ChengState Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, School of Medicine, The First Affiliated Hospital, Zhejiang University, Hangzhou, China.
Li ShaoInstitute of Hepatology and Metabolic Diseases, Hangzhou Normal University, Hangzhou, China.
Xia LiuDepartment of Intensive Care Unit, School of Medicine, The First Affiliated Hospital, Zhejiang University, Hangzhou, China.
Ruilai JiangDepartment of Geriatrics, Lishui Second People's Hospital, Lishui, China.
Shaochang WuDepartment of Geriatrics, Lishui Second People's Hospital, Lishui, China.
Xian Yang Central Hospital · CNFirst Affiliated Hospital Zhejiang University · CNHangzhou Normal University · CNLishui City People's Hospital · CNZhejiang University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Increasing evidence suggests that gut dysbiosis plays vital roles in a variety of gut-brain disorders, such as Alzheimer's disease (AD). However, alterations of the gut microbiota as well as their correlations with cognitive scores and host immunity have remained unclear in well-controlled trials on Chinese AD patients. In this study, samples from 100 AD patients, and 71 age- and gender-matched, cognitively normal controls were obtained to explore the structural and functional alterations of the fecal microbiota targeting the V3-V4 region of the 16S rRNA gene by MiSeq sequencing, and to analyze their associations with clinical characteristics. Our data demonstrated a remarkably reduction in the bacterial diversity and alterations in the taxonomic composition of the fecal microbiota of the AD patients. Interestingly, the abundant butyrate-producing genera such as

Indexed as

Alzheimer's diseaseBifidobacteriumFaecalibacteriumgut-brain axissequencing

Identifiers

PMID33614635
PMCPMC7889981
OpenAlexW3128647245

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.