Evidence map›Paper›PMID 33614551›Full record

ReviewFrontiers in pediatrics2021

FOXP3 and Tip60 Structural Interactions Relevant to IPEX Development Lead to Potential Therapeutics to Increase FOXP3 Dependent Suppressor T Cell Functions.

Payal Grover, Peeyush N Goel, Ciriaco A Piccirillo, Mark I Greene

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in pediatrics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.9field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 12 citations in OpenAlex.

  1. Review
  2. Targeting lysine acetylation readers and writers.Nature reviews. Drug discovery · 2025
    Review
  3. Article
  4. Review
  5. ProbioticNutrients · 2024
    Article
  6. Article
  7. Review
  8. Regulatory T Cells in Autoimmune Vasculitis.Frontiers in immunology · 2022
    Review
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Payal GroverDepartment of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States.
Peeyush N GoelDepartment of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States.
Ciriaco A PiccirilloDepartment of Microbiology and Immunology, McGill University, Montréal, QC, Canada.
Mark I GreeneDepartment of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States.
University of Pennsylvania · USMcGill University Health Centre · CA

Funding

Immunologic aspects of targeted therapy of erbB tumorsR01CA219034 · NCI · UNIVERSITY OF PENNSYLVANIA · PI GREENE, MARK I · 2018 to 2022
$1.8M
NCI NIH HHS R01 CA219034
6 · The paper itself

Abstract

Regulatory T (Treg) cells play a role in the maintenance of immune homeostasis and are critical mediators of immune tolerance. The Forkhead box P3 (FOXP3) protein acts as a regulator for Treg development and function. Mutations in the

Indexed as

acetylationallosteric modifiersFoxp3histone acetyl transferaseIPEXT effector cellTIP60Treg—regulatory T cell

Identifiers

PMID33614551
PMCPMC7888439
OpenAlexW3126213726

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.