ArticleOpen veterinary journal2021
Canine cognitive dysfunction patients have reduced total hippocampal volume compared with aging control dogs: A comparative magnetic resonance imaging study.
Article in Open veterinary journal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 24 citations in OpenAlex.
- Evidence-Based Clinical Management of Canine Cognitive Dysfunction Syndrome: Diagnostic Algorithms, Practical Guidelines, Critical Appraisal of Biomarkers and Translational Limitations.Animals : an open access journal from MDPI · 2026Review
- Canine Cognitive Dysfunction and Alzheimer's Disease: Pathophysiological Relationships and the Impact of Glymphatic System Impairment on Neurodegeneration.Veterinary sciences · 2026Review
- Diffusion tensor imaging analysis of aged dogs with and without canine cognitive dysfunction.BMC veterinary research · 2025Article
- Diagnosis of Canine Cognitive Dysfunction Syndrome: A Narrative Review.Veterinary sciences · 2025Review
- Dogs' olfactory resting-state functional connectivity is modulated by age and brain shape.Scientific reports · 2025Article
- A diffusion tensor imaging white matter atlas of the domestic canine brain.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Transcranial photobiomodulation therapy improves cognitive test scores in dogs with presumptive canine cognitive dysfunction: A case series of five dogs.Open veterinary journal · 2024Article
- The Olfactory Bulb in Companion Animals-Anatomy, Physiology, and Clinical Importance.Brain sciences · 2023Review
- Winning the race with aging: age-related changes in gait speed and its association with cognitive performance in dogs.Frontiers in veterinary science · 2023Article
- Autologous skin-derived neural precursor cell therapy reverses canine Alzheimer dementia-like syndrome in a proof of concept veterinary trial.Stem cell research & therapy · 2022Article
- Age-related brain atrophy in cats without apparent neurological and behavioral signs using voxel-based morphometry.Frontiers in veterinary science · 2022Article
- Successful and Unsuccessful Brain Aging in Pets: Pathophysiological Mechanisms behind Clinical Signs and Potential Benefits from Palmitoylethanolamide Nutritional Intervention.Animals : an open access journal from MDPI · 2021Review
- Modified formulas for calculation of encephalization: quotient in dogs.BMC research notes · 2021Article
- Transcranial photobiomodulation (laser) therapy for cognitive impairment: A review of molecular mechanisms and potential application to canine cognitive dysfunction (CCD).Open veterinary journalReview
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Hippocampal atrophy is a key pathologic and magnetic resonance imaging (MRI) feature of human Alzheimer's disease (AD). Hippocampal atrophy has not been documented via MRI in canine cognitive dysfunction (CCD), which is considered as the dog model of human AD. Aim: The purpose of this retrospective comparative volumetric MRI study was to compare total hippocampal volumes between successfully aging (control) dogs and dogs diagnosed with CCD. Methods: Mimics Results: Total hippocampal volume normalized to total brain volume was significantly less for CCD patients compared with control dogs ( Conclusion: The results of this study suggest that - similar to human AD - hippocampal atrophy is a pathological feature of CCD. This finding has potential importance for both investigating disease mechanisms related to dementia as well as future hippocampal-targeted therapies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.