Evidence map›Paper›PMID 33614400›Full record

ArticleNanotheranostics2021

Non-radioactive and sensitive tracking of neutrophils towards inflammation using antibody functionalized magnetic particle imaging tracers.

Prashant Chandrasekharan, K L Barry Fung, Xinyi Y Zhou, Weiwen Cui, Caylin Colson, David Mai, Kenneth Jeffris, Quincy Huynh, Chinmoy Saayujya, Leyla Kabuli and 7 more

Open access · goldAbstract read
In one paragraph

Article in Nanotheranostics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
3.0field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 47 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Article
  6. Flame-Made Doped Iron Oxide Nanoparticles as Tracers for Magnetic Particle Imaging.Chemistry of materials : a publication of the American Chemical Society · 2025
    Article
  7. Review
  8. Review
  9. ISMRM Clinical Focus Meeting 2023: "Imaging the Fire in the Brain".Journal of magnetic resonance imaging : JMRI · 2025
    Article
  10. On the partial volume effect in magnetic particle imaging.Physics in medicine and biology · 2025
    Article
  11. Review
  12. Article
  13. Review
  14. Article
  15. Elucidating Iron Metabolism through Molecular Imaging.Current issues in molecular biology · 2024
    Review
  16. Article
  17. FeMaterials (Basel, Switzerland) · 2023
    Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 1 institution in 1 country.

Prashant ChandrasekharanDepartment of Bioengineering, University of California, Berkeley, California 94720, United States.
K L Barry FungDepartment of Bioengineering, University of California, Berkeley, California 94720, United States.
Xinyi Y ZhouDepartment of Bioengineering, University of California, Berkeley, California 94720, United States.
Weiwen CuiDepartment of Bioengineering, University of California, Berkeley, California 94720, United States.
Caylin ColsonDepartment of Bioengineering, University of California, Berkeley, California 94720, United States.
David MaiDepartment of Bioengineering, University of California, Berkeley, California 94720, United States.
Kenneth JeffrisDepartment of Bioengineering, University of California, Berkeley, California 94720, United States.
Quincy HuynhDepartment of Electrical Engineering and Computer Sciences, University of California, Berkeley, California 94720, United States.
Chinmoy SaayujyaDepartment of Electrical Engineering and Computer Sciences, University of California, Berkeley, California 94720, United States.
Leyla KabuliDepartment of Bioengineering, University of California, Berkeley, California 94720, United States.
Benjamin FellowsDepartment of Bioengineering, University of California, Berkeley, California 94720, United States.
Yao LuDepartment of Bioengineering, University of California, Berkeley, California 94720, United States.
Elaine YuDepartment of Bioengineering, University of California, Berkeley, California 94720, United States.
Zhi Wei TayDepartment of Bioengineering, University of California, Berkeley, California 94720, United States.
Bo ZhengDepartment of Bioengineering, University of California, Berkeley, California 94720, United States.
Lawrence FongUCSF Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, California 94143, United States.
Steven M ConollyDepartment of Bioengineering, University of California, Berkeley, California 94720, United States.
University of California, Berkeley · US

Funding

In Vivo Therapeutic Cell Tracking by Advanced Magnetic Particle ImagingR01EB024578 · NIBIB · UNIVERSITY OF CALIFORNIA BERKELEY · PI CONOLLY, STEVEN M · 2017 to 2020
$2.2M
Pre-clinical quantitation of ovarian cancer tumor burden using Magnetic Particle Imaging and non-dilutive cell labelingR01EB019458 · NIBIB · UNIVERSITY OF CALIFORNIA BERKELEY · PI BELL, CALEB B., CONOLLY, STEVEN M · 2015 to 2018
$1.9M
Stem Cell Engineering Training ProgramT32GM098218 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI HEALY, KEVIN EDWARD, SCHAFFER, DAVID V · 2011 to 2020
$1.8M
Color MPI as a novel method for in vivo assessment of magnetic nanoparticle dynamics and bindingR44EB029877 · NIBIB · MAGNETIC INSIGHT, INC. · PI GOODWILL, PATRICK · 2020 to 2021
$1.6M
Magnetic Particle Imaging for High-Resolution Functional Brain ImagingR01EB029822 · NIBIB · UNIVERSITY OF CALIFORNIA BERKELEY · PI CONOLLY, STEVEN M · 2020 to 2020
$815k
NIBIB NIH HHS R01 EB019458NIBIB NIH HHS R01 EB024578NIBIB NIH HHS R01 EB029822NIBIB NIH HHS R44 EB029877NIGMS NIH HHS T32 GM098218
6 · The paper itself

Abstract

White blood cells (WBCs) are a key component of the mammalian immune system and play an essential role in surveillance, defense, and adaptation against foreign pathogens. Apart from their roles in the active combat of infection and the development of adaptive immunity, immune cells are also involved in tumor development and metastasis. Antibody-based therapeutics have been developed to regulate (i.e. selectively activate or inhibit immune function) and harness immune cells to fight malignancy. Alternatively, non-invasive tracking of WBC distribution can diagnose inflammation, infection, fevers of unknown origin (FUOs), and cancer. Magnetic Particle Imaging (MPI) is a non-invasive, non-radioactive, and sensitive medical imaging technique that uses safe superparamagnetic iron oxide nanoparticles (SPIOs) as tracers. MPI has previously been shown to track therapeutic stem cells for over 87 days with a ~200 cell detection limit. In the current work, we utilized antibody-conjugated SPIOs specific to neutrophils for

Indexed as

MagneticsCell TrackingHumansNeutrophilsantibodyinflammationmagnetic particle imagingmedical imagingsuperparamagnetic iron oxide nanoparticleswhite blood cells

Identifiers

PMID33614400
PMCPMC7893534
OpenAlexW3129346579

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.