ArticleClinical psychological science : a journal of the Association for Psychological Science2019
The Critical Need for Help-Seeking Controls in Clinical High-Risk Research.
Article in Clinical psychological science : a journal of the Association for Psychological Science, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 2 of them syntheses that pooled it.
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Who cites it
26 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Neuropsychological Performance Among Individuals at Clinical High-Risk for Psychosis vs Putatively Low-Risk Peers With Other Psychopathology: A Systematic Review and Meta-Analysis.Schizophrenia bulletin · 2022Pooled it
- Sleep and suicide: A systematic review and meta-analysis of longitudinal studies.Clinical psychology review · 2020Pooled it
- Value representation in youth psychopathology: evidence of a transdiagnostic risk mechanism for psychosis.Translational psychiatry · 2026Article
- Reduced interpersonal head synchrony in youth at clinical high risk for psychosis.Psychological medicine · 2025Article
- Identifying individuals at clinical high risk for psychosis using a battery of tasks sensitive to symptom mechanisms.Translational psychiatry · 2025Article
- Interpersonal difficulties and suicidal ideation in young people at clinical high-risk for psychosis and help-seeking clinical controls.Psychiatry research · 2025Article
- Persons at risk for psychosis overestimate social functioning compared to persons with major depressive disorder and community controls.Journal of psychiatric research · 2025Article
- A generalized reward processing deficit pathway to negative symptoms across diagnostic boundaries.Psychological medicine · 2025Article
- Clinical utility of the at-risk for psychosis state beyond transition: A multidimensional network analysis.European child & adolescent psychiatry · 2025Article
- Clinical and Functional Outcomes of Community-Recruited Individuals at Clinical High-Risk for Psychosis: Results From the Youth Mental Health Risk and Resilience Study (YouR-Study).Schizophrenia bulletin open · 2024Article
- Psychosocial stress, interpersonal sensitivity, and social withdrawal in clinical high risk for psychosis: a systematic review.Schizophrenia (Heidelberg, Germany) · 2023Review
- A Review of Potential Neuroimaging Biomarkers of Schizophrenia-Risk.Journal of psychiatry and brain science · 2023Article
- Characterising cognitive heterogeneity in individuals at clinical high-risk for psychosis: a cluster analysis with clinical and functional outcome prediction.European archives of psychiatry and clinical neuroscience · 2022Article
- Identifying Electroencephalography Biomarkers in Individuals at Clinical High Risk for Psychosis in an International Multi-Site Study.Frontiers in psychiatry · 2022Article
- Categorical versus dimensional models of early psychosis.Early intervention in psychiatry · 2022Article
- Linking Salience Signaling With Early Adversity and Affective Distress in Individuals at Clinical High Risk for Psychosis: Results From an Event-Related fMRI Study.Schizophrenia bulletin open · 2022Article
- Employing Contemporary Integrative Interpersonal Theory to Understand Dysfunction in Those at Clinical High Risk for Psychosis.Schizophrenia bulletin open · 2022Article
- Relations Among Anhedonia, Reinforcement Learning, and Global Functioning in Help-seeking Youth.Schizophrenia bulletin · 2021Article
- Predictors of internalized mental health stigma in a help-seeking sample of youth: The roles of psychosis-spectrum symptoms and family functioning.Journal of abnormal psychology · 2021Article
- Enhancing Prediction of Psychosis Risk With Cognitive Measures: How Do We Get to There From Here?JAMA psychiatry · 2021Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Despite rapidly growing knowledge of the clinical high-risk (CHR) state for psychosis, the vast majority of case-control studies have relied on healthy volunteers as a reference point for drawing inferences about the CHR construct. Researchers have long recognized that results generated from this design are limited by significant interpretive concerns, yet little attention has been given to how these concerns affect the growing field of CHR research. We argue that overreliance on healthy controls in CHR research threatens the validity of inferences concerning group differences, hinders advances in understanding the development of psychosis, and limits clinical progress. We suggest that the combined use of healthy and help-seeking (i.e., psychiatric) controls is a necessary step for the next generation of CHR research. We then evaluate methods for help-seeking control studies, identify the available CHR studies that have used such designs, discuss select findings in this literature, and offer recommendations for research.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.