Evidence map›Paper›PMID 33614166›Full record

ArticleImmunometabolism2021

Uncovering New Challenges in Targeting Glycolysis to Treat Th17 Cell-Mediated Autoimmunity.

Sarah A Mosure, Laura A Solt

Open access · diamondAbstract readComment
PubMed Full text at PMC Publisher
In one paragraph

Article in Immunometabolism, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Sarah A MosureDepartment of Immunology and Microbiology, The Scripps Research Institute, Jupiter, FL 33458, USA.
Laura A SoltDepartment of Immunology and Microbiology, The Scripps Research Institute, Jupiter, FL 33458, USA.
Scripps Research Institute · US

Funding

Identification of REV-ERB inverse agonists for cancer immunotherapyR01CA241816 · NCI · UNIVERSITY OF FLORIDA · PI SOLT, LAURA A · 2019 to 2022
$2.5M
Regulation of TH17 Cell Development and Function by the REV-ERBsR01AI116885 · NIAID · SCRIPPS FLORIDA · PI SOLT, LAURA A · 2016 to 2020
$2.1M
Identification of Chemical Probes for the Orphan Nuclear Receptor NR2F6R01CA225890 · NCI · UNIVERSITY OF FLORIDA · PI SCAMPAVIA, LOUIS DANIEL, SOLT, LAURA A · 2018 to 2020
$1.6M
Integrated Acoustic Transfer System for HTS Library ManagementS10OD025279 · OD · SCRIPPS FLORIDA · PI SCAMPAVIA, LOUIS DANIEL · 2018 to 2018
$624k
Regulation of TH17 cell development and function by the REV-ERBsR56AI116885 · NIAID · SCRIPPS FLORIDA · PI SOLT, LAURA A · 2015 to 2015
$480k
HTS Drug  Discovery DispensersS10OD026857 · OD · SCRIPPS FLORIDA · PI SCAMPAVIA, LOUIS DANIEL · 2019 to 2019
$452k
Elucidating the molecular mechanisms underlying ligand-dependent REV-ERB activity in Th17 cellsF31DK127643 · NIDDK · UNIVERSITY OF FLORIDA · PI MOSURE, SARAH · 2021 to 2022
$67k
NCI NIH HHS R01 CA225890NCI NIH HHS R01 CA241816NIAID NIH HHS R01 AI116885NIAID NIH HHS R56 AI116885NIDDK NIH HHS F31 DK127643NIH HHS S10 OD025279NIH HHS S10 OD026857
6 · The paper itself

Abstract

Targeting glycolysis in T helper 17 (Th17) cells presents an attractive opportunity to treat Th17 cell-mediated autoimmune diseases such as multiple sclerosis (MS). Pyruvate kinase isoform 2 (PKM2) is a glycolytic enzyme expressed in T cells infiltrating the central nervous system in a mouse model of MS, suggesting PKM2 modulation could provide a new avenue for MS therapeutics. In a recent article in

Indexed as

glycolysisinflammationmetabolismmultiple sclerosispyruvate kinaseTh17 cell

Identifiers

PMID33614166
PMCPMC7894650
OpenAlexW3123491675

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.