ArticleToxicology research2021
Effects of chlorpyrifos exposure on liver inflammation and intestinal flora structure in mice.
Article in Toxicology research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 39 citations in OpenAlex.
- Chlorpyrifos and Chlorpyrifos-Oxon: A Widening Spectrum of Toxicity.International journal of molecular sciences · 2026Review
- Protective effect of green tea extract on chlorpyrifos induced toxicity in liver of male mice.Scientific reports · 2026Article
- Network toxicology study and key target validation of chlorpyrifos-induced nonalcoholic fatty liver disease.Scientific reports · 2026Article
- Pesticides Drive Liver Diseases Through Non-Apoptotic Regulated Cell Death Pathways.Diseases (Basel, Switzerland) · 2026Review
- Protective effects ofToxicology research · 2025Article
- Hepatoprotective effect of geraniol against chlorpyrifos ethyl-induced liver injury: an experimental animal study.BMC pharmacology & toxicology · 2025Article
- Article
- The Impact of Imidacloprid in Dietary Residues on Intestinal Damage and the Increased Risk of EnterotoxigenicFoods (Basel, Switzerland) · 2025Article
- Involvement of gut microbiota in chlorpyrifos-induced subchronic toxicity in mice.Archives of toxicology · 2025Article
- The effect of fiber intake on the association of pesticide exposure and hypertension: a population-level study.Frontiers in public health · 2025Article
- The hepato- and neuroprotective effect of gold Casuarina equisetifolia bark nano-extract against Chlorpyrifos-induced toxicity in rats.Journal, genetic engineering & biotechnology · 2023Article
- Protective Effect of Baicalin on Chlorpyrifos-Induced Liver Injury and Its Mechanism.Molecules (Basel, Switzerland) · 2023Article
- Article
- The association between organophosphate insecticides and blood pressure dysregulation: NHANES 2013-2014.Environmental health : a global access science source · 2022Article
- Obesity II: Establishing causal links between chemical exposures and obesity.Biochemical pharmacology · 2022Review
- A review of chemical warfare agents linked to respiratory and neurological effects experienced in Gulf War Illness.Inhalation toxicology · 2022Review
- Pinocembrin pretreatment counteracts the chlorpyrifos-induced HO-1 downregulation, mitochondrial dysfunction, and inflammation in the SH-SY5Y cells.Metabolic brain disease · 2021Article
- Chlorpyrifos and ΔCurrent research in toxicology · 2021Review
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chlorpyrifos (CPF) is an organophosphate insecticide commonly used to treat fruit and vegetable crops. CPF can cause severe adverse effects on body organs including the liver and central nervous system. This study investigated the CPF-induced inflammation in mice and explored the role of intestinal flora changes in liver inflammation. Adult C57BL/6 male mice were exposed to a CPF of 0.01-, 0.1-, 1- and 10-mg/kg bodyweight for 12 weeks. The mice in experimental group given CPF solution dissolved in corn oil vehicle by gavage, was administered by intraoral gavage for 5 days per week for 12 weeks. Histopathological examination and inflammatory factor detection were performed on mice liver tissue. Faeces were used for 16S ribosomal RNA high-throughput sequencing to explore the impact of CPF on intestinal flora structure and diversity. The results showed that 1- and 10-mg/kg CPF caused different degrees of liver focal inflammation. The structure of intestinal flora changed significantly in mice including the decreased beneficial bacteria (Akkermansia, Prevotella and Butyricimonas) and increased pathogenic bacteria (Helicobacter and Desulfovibrio). Meanwhile, the results of Q-RT-PCR showed that there was more total bacterial DNA in the liver tissue of the mice treated with 10-mg/kg groups. In conclusion, the imbalance of intestinal flora, the decreased abundance of beneficial bacteria and the increased abundance of pathogenic bacteria, as well as the increase of total bacterial DNA in the liver tissues, maybe associated with the liver focal inflammation induced by CPF.
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Registered trials
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