ArticleJournal of tissue engineering
Human engineered meniscus transcriptome after short-term combined hypoxia and dynamic compression.
Article in Journal of tissue engineering. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed, 16 citations in OpenAlex.
- Functional heterogeneity of meniscal fibrochondrocytes and microtissue models is dependent on modality of fibrochondrocyte isolation.Cell proliferation · 2025Article
- Mechanical Unloading of Engineered Human Meniscus Models Under Simulated Microgravity: A Transcriptomic Study.Scientific data · 2022Article
- Ion modulatory treatments toward functional self-assembled neocartilage.Acta biomaterialia · 2022Article
- Optimizing artificial meniscus by mechanical stimulation of the chondrocyte-laden acellular meniscus using ad hoc bioreactor.Stem cell research & therapy · 2022Article
- A transcriptome software comparison for the analyses of treatments expected to give subtle gene expression responses.BMC genomics · 2022Article
- Engineered Human Meniscus in Modeling Sex Differences of Knee OsteoarthritisFrontiers in bioengineering and biotechnology · 2022Article
- HOX Gene Expressions in Cultured Articular and Nasal Equine Chondrocytes.Animals : an open access journal from MDPI · 2021Article
- Mechano-Hypoxia Conditioning of Engineered Human Meniscus.Frontiers in bioengineering and biotechnology · 2021Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study investigates the transcriptome response of meniscus fibrochondrocytes (MFCs) to the low oxygen and mechanical loading signals experienced in the knee joint using a model system. We hypothesized that short term exposure to the combined treatment would promote a matrix-forming phenotype supportive of inner meniscus tissue formation. Human MFCs on a collagen scaffold were stimulated to form fibrocartilage over 6 weeks under normoxic (NRX, 20% O
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.