Evidence map›Paper›PMID 33613883›Full record

ArticleBasic and clinical neuroscience

The Effects of 3,4-methylenedioxymethamphetamine on Neurogenesis in the Hippocampus of Male Rats.

Sara Soleimani Asl, Fahimeh Ghasemi Moravej, Golshad Kowsari, Mohammad Hassan Farhadi, Bagher Pourhaydar, Hatef Ghasemi Hamidabadi, Mehdi Mehdizadeh

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Basic and clinical neuroscience. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 62% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. [Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Sara Soleimani AslEndometrium and Endometriosis Research Centre, Hamadan University of Medical Sciences, Hamadan, Iran.ORCID https://orcid.org/0000-0003-1518-3308
Fahimeh Ghasemi MoravejEndometrium and Endometriosis Research Centre, Hamadan University of Medical Sciences, Hamadan, Iran.ORCID https://orcid.org/0000-0003-3878-3082
Golshad KowsariSchool of Advanced Technologies in Medicine, Iran University of Medical Sciences, Tehran, Iran.
Mohammad Hassan FarhadiResearcher of Subsance Abuse and Dependence Research Center, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran.ORCID https://orcid.org/0000-0003-0648-7182
Bagher PourhaydarDepartment of Anatomy, Neurophysiology Research Center, School of Medicine, Urmia University of Medical Sciences, Urmia, Iran.ORCID https://orcid.org/0000-0003-3075-9889
Hatef Ghasemi HamidabadiDepartment of Anatomy and Cell Biology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.ORCID https://orcid.org/0000-0002-2178-6503
Mehdi MehdizadehDepartment of Anatomy, Cellular and Molecular Research Center, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.ORCID https://orcid.org/0000-0002-2673-2715
Hamedan University of Medical Sciences · IRIran University of Medical Sciences · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThe administration of 3,4-methylenedioxymethamphetamine (MDMA) or ecstasy causes memory impairment, whereas neurogenesis improves memory and learning. Hence, this study evaluated the effects of MDMA on neurogenesis in the hippocampus of male rats.

methodsAdult male Wistar rats received Intraperitoneal (IP) injections of MDMA (10 mg/ kg). We assessed nestin, sex-determining region Y-box 2 (Sox2), and NeuroD expressions according to the immunohistochemistry analyses.

resultsMDMA reduced the expressions of nestin, Sox2, and NeuroD compared with the control groups. The reduction in NeuroD expression was age-related.

conclusionMDMA possibly has negative effects on neurogenesis, which specifically results from impaired survival of newborn cells.

Indexed as

HippocampusNestinNeuroD ProteinN-Methyl-3,4-methylenedioxyamphetamineSox2 Protein

Identifiers

PMID33613883
PMCPMC7878031
OpenAlexW3004455356

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.