ArticleComputational and structural biotechnology journal2021
A tandem motif-based and structural approach can identify hidden functional phosphodiesterases.
Article in Computational and structural biotechnology journal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 26 citations in OpenAlex.
- Abscisic acid binds to anFrontiers in plant science · 2026Article
- "Cyclic nucleotides in plants: from obscure messengers to central regulators".Frontiers in plant science · 2025Review
- Moonlighting Crypto-Enzymes and Domains as Ancient and Versatile Signaling Devices.International journal of molecular sciences · 2024Review
- Tale of cAMP as a second messenger in auxin signaling and beyond.The New phytologist · 2023Review
- Plant adenylate cyclases have come full circle.Nature plants · 2023Review
- The discovery of hidden guanylate cyclases (GCs) in theComputational and structural biotechnology journal · 2023Article
- Amino acid motifs for the identification of novel protein interactants.Computational and structural biotechnology journal · 2023Review
- New Horizons in Plant Cell Signaling.International journal of molecular sciences · 2022Article
- In Search of Monocot Phosphodiesterases: Identification of a Calmodulin Stimulated Phosphodiesterase fromInternational journal of molecular sciences · 2021Article
- Computational Identification of Functional Centers in Complex Proteins: A Step-by-Step Guide With Examples.Frontiers in bioinformatics · 2021Article
- Functional Crypto-Adenylate Cyclases Operate in Complex Plant Proteins.Frontiers in plant science · 2021Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cyclic nucleotide monophosphates (cNMPs) are increasingly recognized as essential signaling molecules governing many physiological and developmental processes in prokaryotes and eukaryotes. Degradation of cNMPs is as important as their generation because it offers the capability for transient and dynamic cellular level regulation but unlike their generating enzymes, the degrading enzymes, cyclic nucleotide phosphodiesterases (PDEs) are somewhat elusive in higher plants. Based on sequence analysis and structural properties of canonical PDE catalytic centers, we have developed a consensus sequence search motif and used it to identify candidate PDEs. One of these is an
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