Evidence map›Paper›PMID 33613789›Full record

SynthesisDisease markers2021

Inflammatory Markers in Cerebrospinal Fluid from Patients with Hydrocephalus: A Systematic Literature Review.

Sara Diana Lolansen, Nina Rostgaard, Eva Kjer Oernbo, Marianne Juhler, Anja Hviid Simonsen, Nanna MacAulay

Open access · hybridAbstract readSystematic Review
In one paragraph

Synthesis in Disease markers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed, 1 pooled it
4.3field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 1 synthesis or guideline pooled it, 52 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Inflammatory protein profiles and shunt response in iNPH.Fluids and barriers of the CNS · 2026
    Article
  4. Article
  5. Article
  6. Article
  7. Aberrant adenosine ANature communications · 2025
    Article
  8. Article
  9. Review
  10. Review
  11. Article
  12. Review
  13. Article
  14. Review
  15. Article
  16. Article
  17. Paediatric hydrocephalus.Nature reviews. Disease primers · 2024
    Review
  18. Article
  19. Article
  20. Genetic and molecular mechanisms of hydrocephalus.Frontiers in molecular neuroscience · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Sara Diana LolansenDepartment of Neuroscience, University of Copenhagen, Copenhagen, Denmark.ORCID https://orcid.org/0000-0002-6965-0939
Nina RostgaardDepartment of Neurosurgery, Rigshospitalet, Copenhagen, Denmark.ORCID https://orcid.org/0000-0002-6384-9840
Eva Kjer OernboDepartment of Neuroscience, University of Copenhagen, Copenhagen, Denmark.ORCID https://orcid.org/0000-0002-1371-2467
Marianne JuhlerDepartment of Neurosurgery, Rigshospitalet, Copenhagen, Denmark.ORCID https://orcid.org/0000-0003-2652-7495
Anja Hviid SimonsenDanish Dementia Research Centre, Department of Neurology, Rigshospitalet, Copenhagen, Denmark.ORCID https://orcid.org/0000-0002-5461-162X
Nanna MacAulayDepartment of Neuroscience, University of Copenhagen, Copenhagen, Denmark.ORCID https://orcid.org/0000-0002-7800-6600
Rigshospitalet · DKUniversity of Copenhagen · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThe aim of this systematic review was to evaluate existing literature on inflammatory markers in CSF from patients with hydrocephalus and identify potential markers capable of promoting hydrocephalus development and progression.

methodsRelevant studies published before December 3

resultsTwenty-two studies analyzed CSF from 311 patients with idiopathic normal pressure hydrocephalus (iNPH), 178 with posthemorrhagic hydrocephalus (PHH), 151 with other hydrocephalus diagnoses, and 394 control subjects. Fifty-eight inflammatory markers were investigated. The CSF of iNPH patients had increased CSF levels of IL-6, IL-1

conclusionIL-6, IL-1

Indexed as

BiomarkersCase-Control StudiesDisease ProgressionFemaleGene Expression RegulationGlycoproteinsHumansHydrocephalusInflammationInterferon-gammaInterleukin-18Interleukin-1betaInterleukin-6MaleSignal TransductionVascular Endothelial Growth Factor ABiomarkersGlycoproteinsIFNG protein, humanIL1B protein, humanIL6 protein, humanInterferon-gammaInterleukin-18Interleukin-1betaInterleukin-6LRG1 protein, humanVascular Endothelial Growth Factor AVEGFA protein, human

Identifiers

PMID33613789
PMCPMC7875647
OpenAlexW3128280910

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.