ArticleBeilstein journal of organic chemistry2017
Peptide synthesis: ball-milling, in solution, or on solid support, what is the best strategy?
Article in Beilstein journal of organic chemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Shaking Things from the Ground-Up: A Systematic Overview of the Mechanochemistry of Hard and High-Melting Inorganic Materials.Molecules (Basel, Switzerland) · 2023Pooled it
- Mechanochemical Methods for Amide Bond Formation.Chemical reviews · 2026Review
- Mechanochemistry for Metal-Organic Frameworks and Covalent-Organic Frameworks (MOFs, COFs): Methods, Materials, and Mechanisms.Advanced materials (Deerfield Beach, Fla.) · 2025Review
- Listening to the Formation of Polymorphs in a Ball Mill.Analytical chemistry · 2025Article
- Mechanochemistry for Organic and Inorganic Synthesis.ACS organic & inorganic Au · 2024Review
- Direct mechanocatalysis by resonant acoustic mixing (RAM).Chemical science · 2023Article
- Diaryliodonium salts facilitate metal-free mechanoredox free radical polymerizations.Chemical science · 2022Article
- Mechanochemical Synthesis of Primary Amides.The Journal of organic chemistry · 2021Article
- Tribochemistry, Mechanical Alloying, Mechanochemistry: What is in a Name?Frontiers in chemistry · 2021Review
- Greening the synthesis of peptide therapeutics: an industrial perspective.RSC advances · 2020Review
- The B & B approach: Ball-milling conjugation of dextran with phenylboronic acid (PBA)-functionalized BODIPY.Beilstein journal of organic chemistry · 2020Article
- Synthesis of acylglycerol derivatives by mechanochemistry.Beilstein journal of organic chemistry · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
While presenting particularly interesting advantages, peptide synthesis by ball-milling was never compared to the two traditional strategies, namely peptide syntheses in solution and on solid support (solid-phase peptide synthesis, SPPS). In this study, the challenging VVIA tetrapeptide was synthesized by ball-milling, in solution, and on solid support. The three strategies were then compared in terms of yield, purity, reaction time and environmental impact. The results obtained enabled to draw some strengths and weaknesses of each strategy, and to foresee what will have to be implemented to build more efficient and sustainable peptide syntheses in the near future.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.