ReviewExperimental and therapeutic medicine2021
Challenges of phototherapy for neonatal hyperbilirubinemia (Review).
Review in Experimental and therapeutic medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05178433 (Randomized Controlled Study of Skin Care Strategies for Neonatal Jaundice Phototherapy to Prevent Atopic Dermatitis in Moderate and Severe Infants), which is not on this map. Cited by 37 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Randomized Controlled Study of Skin Care Strategies for Neonatal Jaundice Phototherapy to Prevent Atopic Dermatitis in Moderate and Severe Infants
Who cites it
37 citing papers in PubMed, 3 syntheses or guidelines pooled it, 92 citations in OpenAlex.
- Efficacy and Safety of Probiotic Supplementation for Neonatal Jaundice: A Systematic Review and Meta-analysis.Probiotics and antimicrobial proteins · 2026Pooled it
- Biological markers of hearing loss in neonates admitted to the neonatal intensive care unit: a systematic review and meta-analysis.Frontiers in neuroscience · 2026Pooled it
- Risk factors for childhood brain tumours: A systematic review and meta-analysis of observational studies from 1976 to 2022.Cancer epidemiology · 2024Pooled it
- Continuous versus intermittent phototherapy in treatment of neonatal jaundice: a randomized controlled trial.European journal of pediatrics · 2024Trial
- Trial
- Determinants of preterm neonatal mortality in two rural district hospitals of Gatsibo, Rwanda.Maternal health, neonatology and perinatology · 2026Article
- Impact of phototherapy on gut microbiota composition and function in neonates with hyperbilirubinemia: a metagenomic analysis.BMC pediatrics · 2026Article
- Investigation of a PID-Based Dynamic Illuminance Control System for Intelligent Neonatal Jaundice Phototherapy Using a Blue Light LED Array.Sensors (Basel, Switzerland) · 2026Article
- Article
- Evaluating the Impact of Phototherapy on Serum Bilirubin Levels and Clinical Outcomes in Neonates: A Single-Center Retrospective Study in a Resource-Limited Setting in Somalia.Pediatric health, medicine and therapeutics · 2026Article
- Docosahexaenoic acid attenuates neuropathological alterations in a rodent model of neonatal bilirubin-induced encephalopathy.Frontiers in medicine · 2026Article
- Review
- Zinc Supplementation Accelerates Bilirubin Reduction in Neonates with Hyperbilirubinemia: A Double-Blind Randomized Clinical Trial.Reports of biochemistry & molecular biology · 2025Article
- Hematological parameter changes and associated factors in neonates with hyperbilirubinemia treated with phototherapy.BMC pediatrics · 2025Article
- Effect ofFrontiers in nutrition · 2025Article
- Risk factors for the development of necrotizing enterocolitis in neonatal hemolytic disease: a mini review.Frontiers in pediatrics · 2025Review
- Neonatal Hyperbilirubinemia in Uganda: Mechanisms, Clinical Consequences, and Health-System Challenges.Pediatric health, medicine and therapeutics · 2025Review
- Effect of intravenous immunoglobulin on the management of Rh- and ABO-mediated hemolytic disease of the newborn.Hematology, transfusion and cell therapy · 2024Article
- Neonatal phototherapy and risk of epilepsy-A Danish population based study.European journal of pediatrics · 2024Article
- Hematological abnormality and associated factors in newborns with hyperbilirubinemia before and after phototherapy at University of Gondar Comprehensive Specialized Hospital.Scientific reports · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Phototherapy is universally recognized as the first option for treating neonatal jaundice due to its unparalleled efficiency and safety in reducing the high serum free bilirubin levels and limiting its neurotoxic effects. However, several studies have suggested that phototherapy may elicit a series of short- and long-term adverse reactions associated with pediatric diseases, including hemolysis, allergic diseases, DNA damage or even cancer. The aim of the present review was to summarize the etiology, mechanism, associated risks and therapeutic strategies for reducing high neonatal serum bilirubin levels. In order to shed light on the negative effects of phototherapy and to encourage implementation of a reasonable and standardized phototherapy scheme in the clinic, the present review sought to highlight the current understanding of the adverse reactions of phototherapy, as it is necessary to further study the mechanism underlying the development of the adverse effects of phototherapy in infants in order to explore novel therapeutic alternatives.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.