ReviewTherapeutic advances in gastroenterology2021
Eosinophilic esophagitis: clinical, endoscopic, histologic and therapeutic differences and similarities between children and adults.
Review in Therapeutic advances in gastroenterology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
39 citing papers in PubMed, 1 synthesis or guideline pooled it, 91 citations in OpenAlex.
- Esophageal and Oropharyngeal Dysphagia: Clinical Recommendations From the United European Gastroenterology and European Society for Neurogastroenterology and Motility.United European gastroenterology journal · 2025Guideline
- Dietary Approaches in Eosinophilic Esophagitis.Nutrients · 2026Review
- Dysregulated IL-2 signaling and T-cell subset shifts are associated with eosinophilic esophagitis activity.Biochemistry and biophysics reports · 2026Article
- Letter: Peripheral Eosinophilia Does Not Correlate With Endoscopic and Histological Activity in Paediatric Eosinophilic Oesophagitis. Authors' Reply.Alimentary pharmacology & therapeutics · 2026Article
- Eosinophilic gastrointestinal diseases.Nature reviews. Disease primers · 2026Review
- Clinical remission in allergy and clinical immunology practice: State of the art and World Allergy Organization (WAO) call to action.The World Allergy Organization journal · 2026Review
- Bridging eosinophilic esophagitis: healthcare transition from pediatric to adult patients.Italian journal of pediatrics · 2026Review
- Eosinophilic Esophagitis as a Complex Th2 Inflammatory Disease: Results of a Prospective Long-Term Study in Children.Digestive diseases (Basel, Switzerland) · 2026Article
- Optimizing proton-pump inhibitor therapy in paediatric eosinophilic esophagitis throughJournal of the Canadian Association of Gastroenterology · 2025Article
- Endoscopic Management of Eosinophilic Esophagitis: A Narrative Review on Diagnosis and Treatment.Journal of clinical medicine · 2025Review
- Dysphagia Among Children-A Single-Center Experience.Journal of clinical medicine · 2025Article
- Eosinophilic esophagitis in children: A multicenter study evaluating current practices in Mexico.The journal of allergy and clinical immunology. Global · 2025Article
- The clinical impact of conventional therapies for adults and adolescents suffering from eosinophilic esophagitis, a type 2 inflammatory chronic disease, and their economic consequences in Italy: Systematic literature review and meta-analysis.The journal of allergy and clinical immunology. Global · 2025Article
- Eosinophilic Esophagitis and Cow's Milk: Mechanisms, Challenges, and Treatment Perspectives.Nutrients · 2025Review
- Presence of eosinophils may represent an earlier stage in achalasia pathogenesis.Therapeutic advances in gastroenterology · 2025Article
- Italian EoExpert panel recommendation for disease control, switching criteria, and follow-up in eosinophilic esophagitis from pediatric to adult age.Therapeutic advances in gastroenterology · 2025Article
- Determinant factors for first-line treatment choice and effectiveness in pediatric eosinophilic esophagitis: an analysis of the EUREOS EoE CONNECT registry.European journal of pediatrics · 2024Article
- Endoscopic Features of Eosinophilic Gastrointestinal Diseases.Immunology and allergy clinics of North America · 2024Review
- Eosinophilic esophagitis in adults and adolescents: epidemiology, diagnostic challenges, and management strategies for a type 2 inflammatory disease.Therapeutic advances in gastroenterology · 2024Review
- A cost-of-illness study of eosinophilic esophagitis in Italy: assessing direct and indirect costs.Frontiers in gastroenterology (Lausanne, Switzerland) · 2024Article
Corrections and comments
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Authors and funding
15 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In the absence of secondary causes, eosinophilic esophagitis (EoE) is a chronic, local, progressive, T-helper type 2 immune-mediated disorder characterized by symptoms of esophageal dysfunction and eosinophil-predominant inflammation. In the last 20 years, the incidence and prevalence of EoE have risen sharply, and the chances of encountering affected patients in clinics and endoscopy rooms have increased. Nevertheless, it is estimated that the mean diagnostic delay of EoE is 4-6 years in both children and adults. Unfortunately, the longer the disease stays unrecognized, the likelier it is for the patient to have persistent or increased esophageal eosinophilic inflammation, to complain of non-resolving symptoms, and to develop fibrotic complications. Early detection depends on the recognition of initial clinical manifestations that vary from childhood to adulthood and even among patients of the same age. The disease phenotype also influences therapeutic approaches that include drugs, dietary interventions, and esophageal dilation. We have herein reviewed epidemiologic, clinical, endoscopic, and histologic features and therapeutic options of EoE focusing on differences and similarities between children and adults that may certainly serve in daily clinical practice.
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