ArticleFrontiers in immunology2020
Tissue Treg Secretomes and Transcription Factors Shared With Stem Cells Contribute to a Treg Niche to Maintain Treg-Ness With 80% Innate Immune Pathways, and Functions of Immunosuppression and Tissue Repair.
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Article in Frontiers in immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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38citing papers in PubMed
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Who cites it
38 citing papers in PubMed.
- Injury polarized CD4Redox biology · 2026Article
- Integrative Omics Analysis Reveals a CD206Barrier immunity · 2026Article
- Precision Immunoregulation in transplantation: The rise of engineered Treg therapies.Molecular biology reports · 2026Review
- Novel Organelle-Based Intracellular Immunity with Mechanistic and Therapeutic Implications.Barrier immunity · 2026Article
- Decoding Treg diversity and dysfunction to advance Treg-based therapies in autoimmune and inflammatory diseases.Frontiers in immunology · 2026Review
- Discovery of Seven ROS-Sensitive Immune Checkpoints and 46 Ligands Mediating Immune Suppression Through T cell-APC Networks.Journal of Cancer · 2026Article
- Alzheimer's disease as an auto-innate immune pathology with potential cell trans-differentiation and enhanced trained immunity in 3xTg-AD mouse model.Journal of Alzheimer's disease : JAD · 2025Article
- Exome-wide association study reveals 7 functional variants associated with ex-vivo drug response in acute myeloid leukemia patients.BMC medical genomics · 2025Article
- The dual role of tissue regulatory T cells in tissue repair: return to homeostasis or fibrosis.Frontiers in immunology · 2025Review
- The predictive value of preoperative inflammatory status for anastomotic leakage after esophagectomy for esophageal cancer.Frontiers in oncology · 2025Article
- Article
- Immune Checkpoints Are New Therapeutic Targets in Regulating Cardio-, and Cerebro-Vascular Diseases and CD4International journal of drug discovery and pharmacology · 2024Article
- Role of FoxP3Human gene therapy · 2024Review
- A humanized IL-2 mutein expands Tregs and prolongs transplant survival in preclinical models.The Journal of clinical investigation · 2024Article
- Perspective: Pathological transdifferentiation-a novel therapeutic target for cardiovascular diseases and chronic inflammation.Frontiers in cardiovascular medicine · 2024Article
- Resolvin D1 promotes the resolution of inflammation in the ACLF rat model by increasing the proportion of Treg cells.Immunity, inflammation and disease · 2023Article
- The amphiregulin/EGFR axis has limited contribution in controlling autoimmune diabetes.Scientific reports · 2023Article
- Article
- Cigarette Smoke Modulates Inflammation and ImmunityAntioxidants & redox signaling · 2023Review
- Aorta- and liver-generated TMAO enhances trained immunity for increased inflammation via ER stress/mitochondrial ROS/glycolysis pathways.JCI insight · 2023Article
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Authors and funding
19 authors.
Ruijing ZhangCenters for Cardiovascular Research, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, United States.
Keman XuCenters for Cardiovascular Research, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, United States.
Ying ShaoCenters for Cardiovascular Research, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, United States.
Yu SunCenters for Cardiovascular Research, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, United States.
Jason SaredyMetabolic Disease Research & Thrombosis Research, Departments of Pharmacology, Microbiology and Immunology, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, United States.
Elizabeth CutlerCenters for Cardiovascular Research, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, United States.
Tian YaoShanxi Medical University, Shanxi, China.
Ming LiuCenters for Cardiovascular Research, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, United States.
Lu LiuMetabolic Disease Research & Thrombosis Research, Departments of Pharmacology, Microbiology and Immunology, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, United States.
Charles Drummer IvCenters for Cardiovascular Research, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, United States.
Yifan LuCenters for Cardiovascular Research, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, United States.
Fatma SaaoudCenters for Cardiovascular Research, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, United States.
Dong NiCenters for Cardiovascular Research, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, United States.
Jirong WangCenters for Cardiovascular Research, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, United States.
Yafeng LiDepartment of Nephrology, The Affiliated People's Hospital of Shanxi Medical University, Shanxi, China.
Rongshan LiDepartment of Nephrology, The Affiliated People's Hospital of Shanxi Medical University, Shanxi, China.
Xiaohua JiangCenters for Cardiovascular Research, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, United States.
Hong WangMetabolic Disease Research & Thrombosis Research, Departments of Pharmacology, Microbiology and Immunology, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, United States.
Xiaofeng YangCenters for Cardiovascular Research, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, United States.
Funding
CD40 monocyte in chronic kidney diseaseR01DK113775 · NIDDK · TEMPLE UNIV OF THE COMMONWEALTH · PI WANG, HONG · 2017 to 2021
$3.3MCaspase-1 activation mediates chronic kidney disease-accelerated atherosclerosisR01HL131460 · NHLBI · TEMPLE UNIV OF THE COMMONWEALTH · PI CHOI, ERIC T., WANG, HONG · 2016 to 2019
$2.8MThe roles of miR-155 in regulating atherosclerosis and metabolically healthy obesityR01HL138749 · NHLBI · TEMPLE UNIV OF THE COMMONWEALTH · PI YANG, XIAOFENG · 2017 to 2020
$2.6MIL-35 inhibits gut microbiota-produced uremic toxin-accelerated endothelial cell activationR01HL147565 · NHLBI · TEMPLE UNIV OF THE COMMONWEALTH · PI YANG, XIAOFENG · 2019 to 2022
$2.6MAtherogenic roles of complement systemR01HL130233 · NHLBI · TEMPLE UNIV OF THE COMMONWEALTH · PI QIN, XUEBIN, WANG, HONG · 2016 to 2019
$2.5MHHcy-induced Inflammatory Monocyte and Macrophage Differentiation in DiabetesR01DK104116 · NIDDK · TEMPLE UNIV OF THE COMMONWEALTH · PI WANG, HONG · 2015 to 2019
$2.2MNHLBI NIH HHS R01 HL130233NHLBI NIH HHS R01 HL131460NHLBI NIH HHS R01 HL138749NHLBI NIH HHS R01 HL147565NIDDK NIH HHS R01 DK104116NIDDK NIH HHS R01 DK113775
Abstract
We used functional -omics angles and examined transcriptomic heterogeneity in CD4
Indexed as
Immune ToleranceImmunity, InnateCellular MicroenvironmentHumansKruppel-Like Factor 4Stem CellsT-Lymphocytes, RegulatoryTranscription FactorsKLF4 protein, humanKruppel-Like Factor 4Transcription FactorsCD4+Foxp3+ regulatory T cells (Treg)stem cell secretomes and TFsTreg CD markersTreg secretomeTreg transcription factors (TFs)
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.