Evidence map›Paper›PMID 33613517›Full record

ArticleFrontiers in immunology2020

In-Depth Analysis of the Impact of Different Serum-Free Media on the Production of Clinical Grade Dendritic Cells for Cancer Immunotherapy.

João Calmeiro, Luís Mendes, Iola F Duarte, Catarina Leitão, Adriana R Tavares, Daniel Alexandre Ferreira, Célia Gomes, João Serra, Amílcar Falcão, Maria Teresa Cruz and 2 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 18 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

João CalmeiroFaculty of Pharmacy, University of Coimbra, Coimbra, Portugal.
Luís MendesCICECO, Aveiro Institute of Materials, Department of Chemistry, University of Aveiro, Aveiro, Portugal.
Iola F DuarteCICECO, Aveiro Institute of Materials, Department of Chemistry, University of Aveiro, Aveiro, Portugal.
Catarina LeitãoDepartment of Medical Sciences and Institute of Biomedicine (iBiMED), University of Aveiro, Aveiro, Portugal.
Adriana R TavaresFaculty of Pharmacy, University of Coimbra, Coimbra, Portugal.
Daniel Alexandre FerreiraCoimbra Institute for Clinical and Biomedical Research (iCBR), Faculty of Medicine, University of Coimbra, Coimbra, Portugal.
Célia GomesCoimbra Institute for Clinical and Biomedical Research (iCBR), Faculty of Medicine, University of Coimbra, Coimbra, Portugal.
João SerraTecnimede Group, Sintra, Portugal.
Amílcar FalcãoFaculty of Pharmacy, University of Coimbra, Coimbra, Portugal.
Maria Teresa CruzFaculty of Pharmacy, University of Coimbra, Coimbra, Portugal.
Mylène A CarrascalTecnimede Group, Sintra, Portugal.
Bruno Miguel NevesDepartment of Medical Sciences and Institute of Biomedicine (iBiMED), University of Aveiro, Aveiro, Portugal.
University of Coimbra · PTUniversity of Aveiro · PT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dendritic cell (DC)-based antitumor vaccines have proven to be a safe approach, but often fail to generate robust results between trials. Translation to the clinic has been hindered in part by the lack of standard operation procedures for vaccines production, namely the definition of optimal culture conditions during

Indexed as

Batch Cell Culture TechniquesCulture Media, Serum-FreeImmunotherapyBiomarkersCell DifferentiationCytokinesCytotoxicity Tests, ImmunologicDendritic CellsHumansImmunophenotypingKiller Cells, NaturalLymphocyte ActivationNeoplasmsPhagocytosisPrimary Cell CultureBiomarkersCulture Media, Serum-FreeCytokinescancer immunotherapyclinical grade serum-free mediaCTL primingdendritic cell differentiationdendritic cell-NK cell crosstalkdendritic cells vaccinesmetabolic activity

Identifiers

PMID33613517
PMCPMC7893095
OpenAlexW3126152334

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.