SynthesisFrontiers in neurology2021
Identification of Potential Meniere's Disease Targets in the Adult Stria Vascularis.
Synthesis in Frontiers in neurology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- A Systematic Review on the Role of the Stria Vascularis in Menière's Disease Pathogenesis.Journal of the Association for Research in Otolaryngology : JARO · 2025Pooled it
- Utilizing Single Cell RNA-Sequencing to Implicate Cell Types and Therapeutic Targets for SSNHL in the Adult Cochlea.Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology · 2021Pooled it
- A single-nucleus transcriptomic atlas of human inner ear development.Nature neuroscience · 2026Article
- Cochlear Neural Degeneration Is Widespread in Ménière's Disease: A Temporal Bone Study.Journal of the Association for Research in Otolaryngology : JARO · 2026Article
- Changes in the Neurovascular Unit in Meniere's Disease.Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology · 2025Article
- Whole genome DNA methylation profiles define Meniere's disease subclusters.Journal of molecular medicine (Berlin, Germany) · 2025Article
- Cochlear Cell Atlas of Two Laryngeal Echolocating Bats-New Evidence for the Adaptive Nervous Physiology in Constant Frequency Bat.Molecular ecology resources · 2025Article
- Ménière's disease and vestibular migraine: a narrative review of pathogenetic insights, diagnostic evolution, and clinical management advances.Frontiers in neurology · 2025Review
- Article
- Advance and Application of Single-cell Transcriptomics in Auditory Research.Neuroscience bulletin · 2024Review
- Human blood-labyrinth barrier on a chip: a uniqueRSC advances · 2023Article
- RotaRod and acoustic startle reflex performance of two potential mouse models for Meniere's disease.The European journal of neuroscience · 2023Article
- ZBTB20 is essential for cochlear maturation and hearing in mice.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Bats experience age-related hearing loss (presbycusis).Life science alliance · 2023Article
- Dissection of Adult Mouse Stria Vascularis for Single-Nucleus Sequencing or Immunostaining.Journal of visualized experiments : JoVE · 2023Article
- In Silico Localization of Perilymph Proteins Enriched in Meńier̀e Disease Using Mammalian Cochlear Single-cell Transcriptomics.Otology & neurotology open · 2023Article
- The role of the stria vascularis in neglected otologic disease.Hearing research · 2023Review
- Na/K-ATPase Gene Expression in the Human Cochlea: A Study Using mRNAFrontiers in molecular neuroscience · 2022Article
- AFrontiers in cell and developmental biology · 2022Article
- Hearing Function, Degeneration, and Disease: Spotlight on the Stria Vascularis.Frontiers in cell and developmental biology · 2022Review
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
The stria vascularis generates the endocochlear potential and is involved in processes that underlie ionic homeostasis in the cochlear endolymph, both which play essential roles in hearing. The histological hallmark of Meniere's disease (MD) is endolymphatic hydrops, which refers to the bulging or expansion of the scala media, which is the endolymph-containing compartment of the cochlea. This histologic hallmark suggests that processes that disrupt ion homeostasis or potentially endocochlear potential may underlie MD. While treatments exist for vestibular symptoms related to MD, effective therapies for hearing fluctuation and hearing loss seen in MD remain elusive. Understanding the potential cell types involved in MD may inform the creation of disease mouse models and provide insight into underlying mechanisms and potential therapeutic targets. For these reasons, we compare published datasets related to MD in humans with our previously published adult mouse stria vascularis single-cell and single-nucleus RNA-Seq datasets to implicate potentially involved stria vascularis (SV) cell types in MD. Finally, we provide support for these implicated cell types by demonstrating co-expression of select candidate genes for MD within SV cell types.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.