ReviewFrontiers in neurology2021
Acute Traumatic Spinal Cord Injury in Humans, Dogs, and Other Mammals: The Under-appreciated Role of the Dura.
Review in Frontiers in neurology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed, 11 citations in OpenAlex.
- Balloon compression-induced spinal cord injury in canines: a large animal model for spinal cord injury research.Journal of medicine and life · 2024Article
- Hemorrhagic encephalopathies and myelopathies in dogs and cats: a focus on classification.Frontiers in veterinary science · 2024Review
- Case report: Amniotic fluid-derived mesenchymal stem cell treatment in a dog with a spinal cord injury.Veterinary and animal science · 2023Article
- Case report: Traumatic hemorrhagic cervical myelopathy in a dog.Frontiers in veterinary science · 2023Article
- Posterior spinal decompression in adults with spinal cord injury without traumatic compromise of the spinal canal: what is the data?Frontiers in neurology · 2023Review
- Elevated intraspinal pressure in traumatic spinal cord injury is a promising therapeutic target.Neural regeneration research · 2022Review
- Detection and Analysis of Perfusion Pressure through Measuring Oxygen Saturation and Requirement of Dural Incision Decompression after Laminectomy.Computational intelligence and neuroscience · 2021Article
- Contrast-Enhanced Ultrasound Demonstrates a Severity-Dependent Hemodynamic Response to Acute Dural Decompression in Contusive Rodent Spinal Cord Injury.Neurotrauma reportsArticle
- Influential factors of the prognosis of patients with winter sports-induced traumatic cervical spinal cord injury complicated with intramedullary hemorrhage and edema after emergency surgical treatment.Pakistan journal of medical sciencesArticle
- Recovery of ambulation in small, nonbrachycephalic dogs after conservative management of acute thoracolumbar disk extrusion.Journal of veterinary internal medicineArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We review human and animal studies to determine whether, after severe spinal cord injury (SCI), the cord swells against the inelastic dura. Evidence from rodent models suggests that the cord swells because of edema and intraparenchymal hemorrhage and because the pia becomes damaged and does not restrict cord expansion. Human cohort studies based on serial MRIs and measurements of elevated intraspinal pressure at the injury site also suggest that the swollen cord is compressed against dura. In dogs, SCI commonly results from intervertebral disc herniation with evidence that durotomy provides additional functional benefit to conventional (extradural) decompressive surgery. Investigations utilizing rodent and pig models of SCI report that the cord swells after injury and that durotomy is beneficial by reducing cord pressure, cord inflammation, and syrinx formation. A human MRI study concluded that, after extensive bony decompression, cord compression against the dura may only occur in a small number of patients. We conclude that the benefit of routinely opening the dura after SCI is only supported by animal and level III human studies. Two randomized, controlled trials, one in humans and one in dogs, are being set up to provide Level I evidence.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.