ArticleFrontiers in aging neuroscience2021
Differential Patterns of Gyral and Sulcal Morphological Changes During Normal Aging Process.
Article in Frontiers in aging neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 27 citations in OpenAlex.
- Following the curvature: Sulcal versus gyral cortical localization of cerebral microbleeds in cerebral amyloid angiopathy.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2026Article
- Article
- The impact of balance exercise on brain age and brain morphometry: insights from MRI analysis.Aging clinical and experimental research · 2026Observational
- Age-related variations of the hemodynamic response function spatially resolved across human cerebral cortex.Frontiers in aging neuroscience · 2026Article
- Sulcal depth-based individualized structural covariance networks reveal multi-level brain reorganization associated with cognitive performance in COPD.Frontiers in neuroscience · 2026Article
- Creation of structural MRI brain templates for middle to late adulthood in the Thai population using single and multi-scanner data.Quantitative imaging in medicine and surgery · 2025Article
- Motor-cognitive aging: The role of motor cortex and its pathways.NeuroImage · 2025Article
- Cortical Morphological Networks Differ Between Gyri and Sulci.Neuroscience bulletin · 2025Article
- Cortical morphology changes in default mode network regions as predictors of cognitive decline in relation to amyloid and tau deposits.Brain communications · 2025Article
- Structure focused neurodegeneration convolutional neural network for modelling and classification of Alzheimer's disease.Scientific reports · 2024Article
- Defining Overlooked Structures Reveals New Associations between the Cortex and Cognition in Aging and Alzheimer's Disease.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- The glymphatic system and cerebral small vessel disease.Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association · 2024Review
- Depth- and curvature-based quantitative susceptibility mapping analyses of cortical iron in Alzheimer's disease.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Generation of contractile forces by three-dimensional bundled axonal tracts in micro-tissue engineered neural networks.Frontiers in molecular neuroscience · 2024Article
- Systematic cortical thickness and curvature patterns in primates.NeuroImage · 2023Article
- Neural correlates of gait adaptation in younger and older adults.Scientific reports · 2023Article
- Structural differences in the cortex of individuals who experience the autonomous sensory meridian response.Brain and behavior · 2023Article
- Cortical thickness systematically varies with curvature and depth in healthy human brains.Human brain mapping · 2022Article
- Developmental Timing of Trauma in Women Predicts Unique Extracellular Vesicle Proteome Signatures.Biological psychiatry · 2022Article
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 4 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The cerebral cortex is a highly convoluted structure with distinct morphologic features, namely the gyri and sulci, which are associated with the functional segregation or integration in the human brain. During the lifespan, the brain atrophy that is accompanied by cognitive decline is a well-accepted aging phenotype. However, the detailed patterns of cortical folding change during aging, especially the changing age-dependencies of gyri and sulci, which is essential to brain functioning, remain unclear. In this study, we investigated the morphology of the gyral and sulcal regions from pial and white matter surfaces using MR imaging data of 417 healthy participants across adulthood to old age (21-92 years). To elucidate the age-related changes in the cortical pattern, we fitted cortical thickness and intrinsic curvature of gyri and sulci using the quadratic model to evaluate their age-dependencies during normal aging. Our findings show that comparing to gyri, the sulcal thinning is the most prominent pattern during the aging process, and the gyrification of pial and white matter surfaces were also affected differently, which implies the vulnerability of functional segregation during aging. Taken together, we propose a morphological model of aging that may provide a framework for understanding the mechanisms underlying gray matter degeneration.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.