ArticleFrontiers in neuroscience2020
Modeling Circadian Phototransduction: Retinal Neurophysiology and Neuroanatomy.
Article in Frontiers in neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07744711 (Longitudinal Patterns of Use of the Circadian OS iPad-Based Light App, With Optional Biomarker Collection), which is not on this map. Cited by 21 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Longitudinal Patterns of Use of the Circadian OS iPad-Based Light App, With Optional Biomarker Collection
Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Circadian light therapy and light dose for depressed young people: a systematic review and meta-analysis.Frontiers in public health · 2023Pooled it
- High circadian stimulus lighting therapy for depression: Meta-analysis of clinical trials.Frontiers in neuroscience · 2022Pooled it
- Supplemental ambient lighting intervention to improve sleep in Parkinson's disease: A pilot trial.Parkinsonism & related disorders · 2024Trial
- Home-Based Tailored Light Therapy for Sleep, Mood, and Cognitive Outcomes in Mild Cognitive Impairment: A Randomized Trial.Journal of applied gerontology : the official journal of the Southern Gerontological Society · 2026Article
- Circadian Biomarkers Before and After the Transition to Spring Daylight Saving Time.Sleep science (Sao Paulo, Brazil) · 2026Article
- The Impact of a Blue-Blocking Filter Over One Eye on Health and Performance Outcomes and Its Implications for Night Workers.Biological research for nursing · 2026Article
- Comparative Effects of Red and Blue LED Light on Melatonin Levels During Three-Hour Exposure in Healthy Adults.Life (Basel, Switzerland) · 2025Article
- Tailored light intervention for sleep and cognition in World Trade Center (WTC) cohort.Archives of environmental & occupational health · 2025Article
- Days to re-entrainment following the spring and autumn changes in local clock time: Beyond simple heuristics.Frontiers in photonics · 2024Article
- Postoperative cognitive dysfunction: spotlight on light, circadian rhythms, and sleep.Frontiers in neuroscience · 2024Review
- Individual light history matters to deal with the Antarctic summer.Scientific reports · 2023Article
- Evaluation of a Novel Ambient Light Survey Question in the Cancer Prevention Study-3.International journal of environmental research and public health · 2023Article
- Tailored lighting intervention (TLI) for improving sleep-wake cycles in older adults living with dementia.Frontiers in physiology · 2023Article
- Electric lighting, adolescent sleep and circadian outcomes, and recommendations for improving light health.Sleep medicine reviews · 2022Review
- Evaluation of environmental, social, and behavioral modulations of the circadian phase of dancers trained in shifts.iScience · 2022Article
- The circadian stimulus-oscillator model: Improvements to Kronauer's model of the human circadian pacemaker.Frontiers in neuroscience · 2022Article
- Spatial sensitivity of human circadian response: Melatonin suppression from on-axis and off-axis light exposures.Neurobiology of sleep and circadian rhythms · 2021Article
- Lighting and Alzheimer's Disease and Related Dementias: Spotlight on Sleep and Depression.Lighting research & technology (London, England : 2001) · 2021Article
- Relative light sensitivities of four retinal hemi-fields for suppressing the synthesis of melatonin at night.Neurobiology of sleep and circadian rhythms · 2021Article
- Intermittent Light Exposures in Humans: A Case for Dual Entrainment in the Treatment of Alzheimer's Disease.Frontiers in neurology · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
The retina is a complex, but well-organized neural structure that converts optical radiation into neural signals that convey photic information to a wide variety of brain structures. The present paper is concerned with the neural circuits underlying phototransduction for the central pacemaker of the human circadian system. The proposed neural framework adheres to orthodox retinal neuroanatomy and neurophysiology. Several postulated mechanisms are also offered to account for the high threshold and for the subadditive response to polychromatic light exhibited by the human circadian phototransduction circuit. A companion paper, modeling circadian phototransduction: Quantitative predictions of psychophysical data, provides a computational model for predicting psychophysical data associated with nocturnal melatonin suppression while staying within the constraints of the neurophysiology and neuroanatomy offered here.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.