Evidence map›Paper›PMID 33613097›Full record

ReviewCentral-European journal of immunology2020

The role of

Karolina Kaźmierczak-Siedlecka, Agnieszka Daca, Marcin Folwarski, Jacek M Witkowski, Ewa Bryl, Wojciech Makarewicz

Registry-linked trialOpen access · goldAbstract readReview
In one paragraph

Review in Central-European journal of immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06521879 (Improved Gastrointestinal Tolerance and Iron Status Via Probiotic Use in Iron Deficiency Anemia Patients Initiating Oral Iron Replacement), which is not on this map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
6.1field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06521879 nacompletednot on this mapstarted 2022, after this paper: background citation

Improved Gastrointestinal Tolerance and Iron Status Via Probiotic Use in Iron Deficiency Anemia Patients Initiating Oral Iron Replacement

TypeinterventionalSponsorAntalya Training and Research HospitalRan2022 to 2023Enrolled295ConditionsIron Deficiency Anemia Treatment, Iron Deficiency AnemiaArmsLactobacillus plantarum 299v probiotic support
3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 59 citations in OpenAlex.

  1. Trial
  2. Article
  3. Review
  4. Article
  5. Review
  6. Article
  7. Article
  8. Review
  9. ACS omega · 2025
    Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Journal of microbiology and biotechnology · 2024
    Article
  19. ReFermFrontiers in medicine · 2024
    Article
  20. Frontiers in microbiology · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Karolina Kaźmierczak-SiedleckaDepartment of Surgical Oncology, Medical University of Gdansk, Gdansk, Poland.
Agnieszka DacaDepartment of Pathology and Experimental Rheumatology, Medical University of Gdansk, Gdansk, Poland.
Marcin FolwarskiDepartment of Clinical Nutrition and Dietetics, Medical University of Gdansk, Gdansk, Poland.
Jacek M WitkowskiDepartment of Physiopathology, Medical University of Gdansk, Gdansk, Poland.
Ewa BrylDepartment of Pathology and Experimental Rheumatology, Medical University of Gdansk, Gdansk, Poland.
Wojciech MakarewiczDepartment of Surgical Oncology, Medical University of Gdansk, Gdansk, Poland.
Gdańsk Medical University · PL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Alterations in composition of human gut microbiome can lead to its dysbiosis. It is associated with gastrointestinal side effects during anti-cancer treatment, antibiotics administration, or infectious agents. There are studies confirming positive effect of consuming Lactobacillus plantarum 299v on intestinal microflora. This review summarizes the current knowledge about the role of L. plantarum 299v in supporting treatment of selected diseases, such as cancer, irritable bowel syndrome (IBS), and Clostridium difficile infection. The immunomodulating properties of L. plantarum 299v include an increase in the level of anti-inflammatory cytokines, which reduce the risk of cancer and improve the efficacy of regimens. The intake of L. plantarum 299v provides benefits for IBS patients, mainly due to normalization of stool and relief of abdominal pain, which significantly improves the quality of life of IBS patients. In addition, the intake of L. plantarum 299v prevents C. difficile-associated diarrhea among patients receiving antibiotic treatment. Due to the limited possibilities of treating these diseases and numerous complications of cancer treatment, there is a need for new therapeutic strategies. The administration of L. plantarum 299v seems to be useful in these cases.

Indexed as

cancerClostridium difficile infectiondiarrheairritable bowel syndromeLactobacillus plantarum 299v

Identifiers

PMID33613097
PMCPMC7882405
OpenAlexW3131084640

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.