Evidence map›Paper›PMID 33613092›Full record

ArticleCentral-European journal of immunology2020

Expression and regulation of macrophage-inducible C-type lectin in human synovial macrophages.

Mitsutoshi Moriya, Kentaro Uchida, Shotaro Takano, Dai Iwase, Gen Inoue, Manabu Muaki, Ryo Tazawa, Jun Aikawa, Hiroyuki Sekiguchi, Masashi Takaso

Open access · goldAbstract read
In one paragraph

Article in Central-European journal of immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
0.2field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 6 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Mitsutoshi MoriyaDepartment of Orthopedic Surgery, Kitasato University School of Medicine, Sagamihara City, Kanagawa, Japan.
Kentaro UchidaDepartment of Orthopedic Surgery, Kitasato University School of Medicine, Sagamihara City, Kanagawa, Japan.
Shotaro TakanoDepartment of Orthopedic Surgery, Kitasato University School of Medicine, Sagamihara City, Kanagawa, Japan.
Dai IwaseDepartment of Orthopedic Surgery, Kitasato University School of Medicine, Sagamihara City, Kanagawa, Japan.
Gen InoueDepartment of Orthopedic Surgery, Kitasato University School of Medicine, Sagamihara City, Kanagawa, Japan.
Manabu MuakiDepartment of Orthopedic Surgery, Kitasato University School of Medicine, Sagamihara City, Kanagawa, Japan.
Ryo TazawaDepartment of Orthopedic Surgery, Kitasato University School of Medicine, Sagamihara City, Kanagawa, Japan.
Jun AikawaDepartment of Orthopedic Surgery, Kitasato University School of Medicine, Sagamihara City, Kanagawa, Japan.
Hiroyuki SekiguchiShonan University of Medical Sciences Research Institute, Chigasaki City, Kanagawa, Japan.
Masashi TakasoDepartment of Orthopedic Surgery, Kitasato University School of Medicine, Sagamihara City, Kanagawa, Japan.
Kitasato University · JPShonan University of Medical Sciences · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Recent evidence suggests that synovial macrophage activation may be involved in cartilage destruction and pain in osteoarthritis (OA). The macrophage-inducible C-type lectin (Mincle) Clec4e is expressed in macrophages and is regulated in inflammatory conditions. Given that the regulation of Mincle in synovial macrophages has not been elucidated, we investigated the expression and regulation of Mincle in human synovial tissue (ST) harvested from patients with radiographic knee OA during total knee arthroplasty. Immunohistochemical and flow cytometric analyses were used to identify cells with Mincle expression in resected tissues. CD14-positive (CD14

Indexed as

Mincleosteoarthritissynovial tissuetumor necrosis factor-α

Identifiers

PMID33613092
PMCPMC7882416
OpenAlexW3131543391

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.