Evidence map›Paper›PMID 33612491›Full record

ArticleIndian pediatrics2021

Long term Immunogenicity of Single Dose of Live Attenuated Hepatitis A Vaccine in Indian Children - Results of 15-Year Follow-up.

Sheila Bhave, Amita Sapru, Ashish Bavdekar, Rishi Jain, Khokan Debnath, Vaibhavi Kapatkar

Open access · bronzeAbstract read
In one paragraph

Article in Indian pediatrics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.4field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

  1. Age-stratified prevalence of anti-hepatitis A virus antibodies in four metropolitan Indian cities and recent changes in Pune city.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2026
    Article
  2. Article
  3. Hepatitis A virus endemicity and vaccine policy, India.Bulletin of the World Health Organization · 2026
    Article
  4. Review
  5. Article
  6. Hepatitis A virus infection.Nature reviews. Disease primers · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Sheila BhaveDepartment of Pediatrics, KEM Hospital Research Centre, Pune, Maharashtra. Correspondence to: Dr Sheila Bhave, Consultant in Pediatric Research, Department of Pediatrics, KEM Hospital Research Centre, Rasta Peth, Pune 411 011, India. peds@kemhrcpune.org.
Amita SapruDepartment of Pediatrics, KEM Hospital Research Centre, Pune, Maharashtra.
Ashish BavdekarDepartment of Pediatrics, KEM Hospital Research Centre, Pune, Maharashtra.
Rishi JainDepartment of Medical Affairs, Wockhardt Limited, Mumbai, Maharashtra.
Khokan DebnathDepartment of Medical Affairs, Wockhardt Limited, Mumbai, Maharashtra.
Vaibhavi KapatkarDepartment of Medical Affairs, Wockhardt Limited, Mumbai; Maharashtra.
Dr. D. Y. Patil Medical College, Hospital and Research Centre · INWockhardt Hospitals · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo measure anti-HAV antibodies 15 years after a single dose of live attenuated hepatitis A vaccine in Indian children.

methodsOf the 143 children vaccinated in 2004, 109 were evaluated in 2019, clinically and for anti-HAV antibodies. These children have been assessed clinically every year, and for anti-HAV antibodies in 2004, 2007, 2010 and 2014.

resultsOf the 109 children who came for the present assessment, 11 had received additional doses of hepatitis A vaccine in 2004/2007 because of low anti-HAV titre (<20 mIU/mL). In the remaining 98 children, 94 (96%) had seroprotective levels with a geometric mean titre of 79.6 mIU/mL. Seroprotection rate in all 109 children was 86.2%.

conclusionsSingle dose of live attenuated hepatitis A vaccine in Indian children demonstrated robust immunogenicity at 15 years post vaccination.

Indexed as

Hepatitis AHepatitis A VaccinesChildFollow-Up StudiesHepatitis A AntibodiesHumansVaccines, InactivatedHepatitis A AntibodiesHepatitis A VaccinesVaccines, Inactivated

Identifiers

PMID33612491
PMCPMC8384096
OpenAlexW3131488107

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.