ArticleNutrition, metabolism, and cardiovascular diseases : NMCD2021
BMI trajectory and subsequent risk of type 2 diabetes among middle-aged women.
Article in Nutrition, metabolism, and cardiovascular diseases : NMCD, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 21 citations in OpenAlex.
- Article
- Health status of type 2 diabetic patients attending primary care centers in Puducherry region - An observational study.Journal of family medicine and primary care · 2025Article
- Early-pregnancy per- and polyfluoroalkyl substances and maternal post-pregnancy weight trajectory.Obesity (Silver Spring, Md.) · 2025Article
- Article
- How do sex-specific BMI trajectories shape diabetes risk? A longitudinal analysis of Indonesian adults.BMJ public health · 2023Article
- Effects of a New Group of Antidiabetic Drugs in Metabolic Diseases.Reviews in cardiovascular medicine · 2023Review
- Waist Circumference-Years Construct Analysis and the Incidence of Type 2 Diabetes: China Health and Nutrition Survey, 1997-2015.Nutrients · 2022Article
- Risk of Type 2 Diabetes Among Individuals with Excess Weight: Weight Trajectory Effects.Current diabetes reports · 2022Review
- Moderate physical activity may not decrease the risk of cardiovascular disease in persistently overweight and obesity adults.Journal of translational medicine · 2022Article
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
Abstract
BACKGROUND AND
aimsLittle is known about how weight trajectories among women during menopausal transition and beyond may be related to risk of type 2 diabetes mellitus (T2DM). The aim of this study was to examine associations between body mass index (BMI) trajectories over 20 years, age of obesity onset, cumulative obese-years and incidence of T2DM among middle-aged women. METHODS AND
results12,302 women enrolled in the Australian Longitudinal Study on Women's Health (ALSWH) were surveyed in 1996 (Survey 1, age 45-50), 1998 and then every three years to 2016. Self-reported weight and height were collected for up to eight time points. Incident diabetes was assessed via validated self-report of physician-diagnosed diabetes. Growth mixture models were used to identify distinct BMI trajectories. A total of 1380 (11.2%) women newly developed T2DM over an average 16 years of follow-up. Seven distinct BMI trajectories were identified with differential risk of developing T2DM. Initial BMI was positively associated with T2DM risk. We also observed that risk of T2DM was positively associated with rapid weight increase, early age of obesity onset and greater obese-years.
conclusionSlowing down weight increases, delaying the onset of obesity, or reducing cumulative exposure to obesity may substantially lower the risk of developing T2DM.
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