Evidence map›Paper›PMID 33612137›Full record

ArticleBJPsych open2021

Schizophrenia polygenic risk scores in youth mental health: preliminary associations with diagnosis, clinical stage and functioning.

Jacob J Crouse, Joanne S Carpenter, Frank Iorfino, Tian Lin, Nicholas Ho, Enda M Byrne, Anjali K Henders, Leanne Wallace, Daniel F Hermens, Elizabeth M Scott and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BJPsych open, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Factors associated with anxiety disorder comorbidity.Journal of affective disorders · 2023
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 1 country.

Jacob J CrouseYouth Mental Health & Technology Team, Brain and Mind Centre, University of Sydney, Australia.ORCID https://orcid.org/0000-0002-3805-2936
Joanne S CarpenterYouth Mental Health & Technology Team, Brain and Mind Centre, University of Sydney, Australia.
Frank IorfinoYouth Mental Health & Technology Team, Brain and Mind Centre, University of Sydney, Australia.
Tian LinQueensland Brain Institute, University of Queensland, Australia; and Institute of Molecular Bioscience, University of Queensland, Australia.
Nicholas HoYouth Mental Health & Technology Team, Brain and Mind Centre, University of Sydney, Australia.
Enda M ByrneInstitute of Molecular Bioscience, University of Queensland, Australia.
Anjali K HendersInstitute of Molecular Bioscience, University of Queensland, Australia.
Leanne WallaceInstitute of Molecular Bioscience, University of Queensland, Australia.
Daniel F HermensSunshine Coast Mind and Neuroscience Thompson Institute, University of the Sunshine Coast, Australia.
Elizabeth M ScottSt Vincent's and Mater Clinical School, The University of Notre Dame, Australia.
Naomi R WrayQueensland Brain Institute, University of Queensland, Australia; and Institute of Molecular Bioscience, University of Queensland, Australia.
Ian B HickieYouth Mental Health & Technology Team, Brain and Mind Centre, University of Sydney, Australia.
The University of Queensland · AUThe University of Sydney · AUThe University of Notre Dame Australia · AUUniversity of the Sunshine Coast · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe schizophrenia polygenic risk score (SCZ-PRS) is an emerging tool in psychiatry.

aimsWe aimed to evaluate the utility of SCZ-PRS in a young, transdiagnostic, clinical cohort.

methodSCZ-PRSs were calculated for young people who presented to early-intervention youth mental health clinics, including 158 patients of European ancestry, 113 of whom had longitudinal outcome data. We examined associations between SCZ-PRS and diagnosis, clinical stage and functioning at initial assessment, and new-onset psychotic disorder, clinical stage transition and functional course over time in contact with services.

resultsCompared with a control group, patients had elevated PRSs for schizophrenia, bipolar disorder and depression, but not for any non-psychiatric phenotype (for example cardiovascular disease). Higher SCZ-PRSs were elevated in participants with psychotic, bipolar, depressive, anxiety and other disorders. At initial assessment, overall SCZ-PRSs were associated with psychotic disorder (odds ratio (OR) per s.d. increase in SCZ-PRS was 1.68, 95% CI 1.08-2.59, P = 0.020), but not assignment as clinical stage 2+ (i.e. discrete, persistent or recurrent disorder) (OR = 0.90, 95% CI 0.64-1.26, P = 0.53) or functioning (R = 0.03, P = 0.76). Longitudinally, overall SCZ-PRSs were not significantly associated with new-onset psychotic disorder (OR = 0.84, 95% CI 0.34-2.03, P = 0.69), clinical stage transition (OR = 1.02, 95% CI 0.70-1.48, P = 0.92) or persistent functional impairment (OR = 0.84, 95% CI 0.52-1.38, P = 0.50).

conclusionsIn this preliminary study, SCZ-PRSs were associated with psychotic disorder at initial assessment in a young, transdiagnostic, clinical cohort accessing early-intervention services. Larger clinical studies are needed to further evaluate the clinical utility of SCZ-PRSs, especially among individuals with high SCZ-PRS burden.

Indexed as

early interventionGeneticspsychiatrytransdiagnosticyouth mental health

Identifiers

PMID33612137
PMCPMC8058892
OpenAlexW3130726440

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.