ReviewPhysiological reports2021
Burkitt lymphoma and lactic acidosis: A case report and review of the literature.
Review in Physiological reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed, 20 citations in OpenAlex.
- The multifaceted functions of lactate and its translational potentials in cancer.Frontiers in pharmacology · 2026Review
- Persistent lactic acidosis in ALK-positive anaplastic large cell lymphoma: a case report and literature review.Frontiers in oncology · 2026Article
- A narrative review on the lactic acidosis and hypoglycemia in burkitt lymphoma: navigating metabolic changes.Annals of medicine and surgery (2012) · 2025Review
- Refractory Hypoglycemia Secondary to the Warburg Effect in Diffuse Large B-Cell Lymphoma.JCEM case reports · 2025Article
- Cancer's Metabolic Hijack: The Under-Recognized Hematologic Emergency Related to the Warburg Effect.Cureus · 2025Article
- Article
- Impact of Primary Tumor Resection on Type B Lactic Acidosis in a Case of Metastatic Colon Cancer.Cureus · 2024Article
- Severe Lactic Acidosis and Hypoglycemia Associated With Burkitt Lymphoma and the Warburg Effect.Cureus · 2024Article
- B-cell hepatosplenic lymphoma presenting in adult patient after spontaneous splenic rupture followed by severe persistent hypoglycaemia: type B lactic acidosis and acute liver failure.BMJ case reports · 2023Article
- Lactic acidosis in a patient with cancer.Clinical medicine (London, England) · 2023Article
- The Significance of Microenvironmental and Circulating Lactate in Breast Cancer.International journal of molecular sciences · 2023Review
- Article
- The Aurora kinase inhibitor AT9283 inhibits Burkitt lymphoma growth by regulating Warburg effect.PeerJ · 2023Article
- Lactate/albumin ratio as a predictor of in-hospital mortality in critically ill children.BMC pediatrics · 2022Article
- Type B lactic acidosis associated with diffuse large B-cell lymphoma and the Warburg effect.The Journal of international medical research · 2022Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Type A lactic acidosis is a potentially life-threatening complication in critically ill patients and is the hallmark of a shock state as a result of tissue hypoperfusion and dysoxia. Type B lactic acidosis results from mechanisms other than dysoxia and is a rare condition in patients with solid tumors or hematological malignancies. We present a case of a 60-year-old man with lactic acidosis who was found to have a Burkitt lymphoma related to a posttransplant lymphoproliferative disorder. Lactagenic cancers are characterized by increased aerobic glycolysis and excessive lactate formation, a phenomenon described by Warburg in 1923 that is correlated with cancer aggressiveness and poor survival. There is increased glucose utilization with the purpose of lactagenesis under fully oxygenated conditions, as lactate seems to be a potent signaling molecule for angiogenesis, immune escape, cell migration, metastasis and self-sufficient metabolism, which are five essential steps of carcinogenesis. Type B lactic acidosis in association with malignancies carries an extremely poor prognosis. Currently, effective chemotherapy seems to be the only hope for survival.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.