Evidence map›Paper›PMID 33611829›Full record

ArticleThe Kaohsiung journal of medical sciences2021

Cigarette smoke extract promotes DNA methyltransferase 3a expression in dendritic cells, inducing Th-17/Treg imbalance via the c-Jun/allograft inflammatory factor 1 axis.

Dan Huang, Bin Zhou, Zhen-Zhong Luo, Shu-Chun Yu, Bin Tang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Kaohsiung journal of medical sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.5field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Frontiers in cellular and infection microbiology · 2023
    Article
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Dan HuangDepartment of Anesthesiology, The Second Affiliated Hospital of Nanchang University, Nanchang, P.R. China.
Bin ZhouDepartment of Anesthesiology, The Second Affiliated Hospital of Nanchang University, Nanchang, P.R. China.
Zhen-Zhong LuoDepartment of Anesthesiology, The Second Affiliated Hospital of Nanchang University, Nanchang, P.R. China.
Shu-Chun YuDepartment of Anesthesiology, The Second Affiliated Hospital of Nanchang University, Nanchang, P.R. China.
Bin TangDepartment of Respiratory Medicine, Jiangxi Provincial People's Hospital Affiliated to Nanchang University, Nanchang, P.R. China.ORCID https://orcid.org/0000-0002-2629-3919
Nanchang University · CN

Funding

The Science and Technology Plan of Jiangxi Province Health Committee 20204366The Science and Technology Plan of Jiangxi Province Health Committee, Grant/Award Number: 20204366The Science and Technology Plan of Jiangxi Provincial Health and Family Planning Committee 20181001The Science and Technology Plan of Jiangxi Provincial Health and Family Planning Committee, Grant/Award Number: 20181001
6 · The paper itself

Abstract

Chronic obstructive pulmonary disease (COPD) is a chronic respiratory disorder. Although numerous studies on COPD have been conducted, therapeutic strategies for COPD are limited, and its pathological mechanism is still unclear. The present study aimed to explore the role of DNA methyltransferase 3a (DNMT3a) in dendritic cells (DCs) and the possible role of the Th-17/Treg cell balance in COPD. Immature DCs (iDCs) were induced and cocultured with CD4

Indexed as

SmokeAllograftsAnimalsAnthracenesCalcium-Binding ProteinsCD4-Positive T-LymphocytesCell DifferentiationCells, CulturedDendritic CellsDisease Models, AnimalDNA Methyltransferase 3AEnzyme InhibitorsMaleMiceMice, Inbred BALB CMicrofilament ProteinsAif1 protein, mouseAnthracenesCalcium-Binding ProteinsDNA Methyltransferase 3ADnmt3a protein, mouseEnzyme InhibitorsMicrofilament ProteinsProto-Oncogene Proteins c-junpyrazolanthroneSmokeTetrazolium SaltsThiazolesthiazolyl bluec-Jun/AIF1 axisCOPDdendritic cellsDNMT3aTh-17/Treg balance

Identifiers

PMID33611829
PMCPMC11896464
OpenAlexW3132482121

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.