ReviewDrug delivery and translational research2021
Therapy of infected wounds: overcoming clinical challenges by advanced drug delivery systems.
Review in Drug delivery and translational research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers.
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Who cites it
56 citing papers in PubMed.
- Advanced antibacterial wound management: comparative study of non-antibiotic drug elution and nanoparticle integration.International journal of pharmaceutics: X · 2026Article
- Biological profiling of structurally diverse LEGO-LPPOs reveals differences in antibacterial activity, cytocompatibility, and in vivo tolerability.The Journal of antibiotics · 2026Article
- Surgical Humidification (HumiGardGlobal spine journal · 2026Article
- Marine-Derived Polyketides fromACS pharmacology & translational science · 2026Article
- Study on the Preparation of a Photo-Responsive Hydrogel Loaded with Berberine-Asiaticoside Cocrystal and Its Therapeutic Effect on Infected Wounds.Gels (Basel, Switzerland) · 2026Article
- Enzyme responsive antimicrobial hyaluronan-nanocellulose hybrid wound dressings for the treatment of infected wounds.Bioactive materials · 2026Article
- Electrospun Poly(caprolactone)/Poly(ethylene oxide) Membranes Incorporating Green-Synthesized Zinc Oxide Nanoparticles for Enhanced Wound Healing Applications.Small science · 2026Article
- <p>Molecular medicine reports · 2026Review
- Development of an Antimicrobial Nanoemulsion Based onPharmaceutics · 2026Article
- The Use of Biomass from In Vitro Fungal Cultures as a Bioactive Ingredient with Antimicrobial Activity in Hydrogel Dressings.Pharmaceuticals (Basel, Switzerland) · 2026Article
- Unveiling the Antioxidant Profiling, Cytotoxicity and Wound Healing Potential of Biocompatible Silver Nanoparticles Synthesized UsingFood science & nutrition · 2026Article
- Harnessing Polymeric Xerogels for Enhanced Wound Care: Properties, Mechanisms, and Applications.ACS materials Au · 2026Review
- The Crucial Role of Noncovalent Interactions in PLGA Nanoparticles: Impact on Carvacrol/ACS omega · 2026Article
- Cathelicidin-like Peptide for ResistantAntibiotics (Basel, Switzerland) · 2026Article
- Prevalence and determinants of infection risk in hospitalised adults: a multicentre cross-sectional study using a structured risk assessment tool.Frontiers in public health · 2026Observational
- Multifunctional Metal Polyphenol Nanoparticles Based on Photothermal Therapy for Bacterial Eradication and Wound Healing.Biomaterials research · 2026Article
- Programmed nanozyme hydrogel enabling spatiotemporal modulation of wound healing achieves skin regeneration after biofilm infection.Journal of nanobiotechnology · 2025Article
- Purified Native Collagen Extracellular Matrix Plus Polyhexamethylene Biguanide Functions as a Barrier to Protect Complex Wounds in an In Vivo Model.International journal of molecular sciences · 2025Article
- Article
- Phloxine B-loaded polymersomes enable eradication ofRSC advances · 2025Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In recent years, the incidence of infected wounds is steadily increasing, and so is the clinical as well as economic interest in effective therapies. These combine reduction of pathogen load in the wound with general wound management to facilitate the healing process. The success of current therapies is challenged by harsh conditions in the wound microenvironment, chronicity, and biofilm formation, thus impeding adequate concentrations of active antimicrobials at the site of infection. Inadequate dosing accuracy of systemically and topically applied antibiotics is prone to promote development of antibiotic resistance, while in the case of antiseptics, cytotoxicity is a major problem. Advanced drug delivery systems have the potential to enable the tailor-made application of antimicrobials to the side of action, resulting in an effective treatment with negligible side effects. This review provides a comprehensive overview of the current state of treatment options for the therapy of infected wounds. In this context, a special focus is set on delivery systems for antimicrobials ranging from semi-solid and liquid formulations over wound dressings to more advanced carriers such as nano-sized particulate systems, vesicular systems, electrospun fibers, and microneedles, which are discussed regarding their potential for effective therapy of wound infections. Further, established and novel models and analytical techniques for preclinical testing are introduced and a future perspective is provided.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.