ArticleInfectious diseases and therapy2021
Epidemiology, Susceptibility, and Risk Factors Associated with Mortality in Carbapenem-Resistant Gram-Negative Bacterial Infections Among Abdominal Solid Organ Transplant Recipients: A Retrospective Cohort Study.
Article in Infectious diseases and therapy, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
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Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Global challenges of bacterial infections in organ transplantation: assessment of risk factors and predominant bacterial pathogen profiles threatening liver, kidney, heart, and lung transplant recipients.BMC infectious diseases · 2025Pooled it
- A comprehensive evaluation of risk factors for mortality, infection and colonization associated with CRGNB in adult solid organ transplant recipients: a systematic review and meta-analysis.Annals of medicine · 2024Pooled it
- Treatment Bundle for Bloodstream Infection Caused by Carbapenem-ResistantInfection and drug resistance · 2026Article
- Mechanisms, therapeutic strategies, and emerging therapeutic alternatives for carbapenem resistance in Gram-negative bacteria.Archives of microbiology · 2025Review
- Clinical Characteristics and Independent Risk Factors for Multidrug-ResistantInfection and drug resistance · 2025Article
- Incidence, risk factors and clinical outcome of multidrug-resistant organisms after heart transplantation.World journal of transplantation · 2024Article
- Burden and Management of Multi-Drug Resistant Organism Infections in Solid Organ Transplant Recipients Across the World: A Narrative Review.Transplant international : official journal of the European Society for Organ Transplantation · 2024Review
- The impact of multi-drug resistant Pseudomonas aeruginosa infections on acute pancreatitis patients.BMC infectious diseases · 2023Article
- Clinical Outcomes and Risk Factors for Death following Carbapenem-Resistant Klebsiella pneumoniae Infection in Solid Organ Transplant Recipients.Microbiology spectrum · 2023Article
- Extended-Spectrum Beta-Lactamase and Carbapenem-Resistant Gram-Negative Pathogens in Makkah, Saudi Arabia.Ethiopian journal of health sciences · 2022Article
- Clinical characteristics, drug resistance and death risk factors of Burkholderia cepacia infection in hematopoietic stem cell transplant patients.BMC infectious diseases · 2022Article
- Analysis of nosocomial infection and risk factors in lung transplant patients: a case-control study.Annals of translational medicine · 2022Article
- Risk Factors for Mortality Among Critical Acute Pancreatitis Patients with Carbapenem-Resistant Organism Infections and Drug Resistance of Causative Pathogens.Infectious diseases and therapy · 2022Article
- Risk Factors and Prognosis of Carbapenem-Resistant Organism Colonization and Infection in Acute Cholangitis.Infection and drug resistance · 2022Article
- Challenges of Antimicrobial Resistance and Stewardship in Solid Organ Transplant Patients.Current infectious disease reports · 2022Review
- Prognostic Risk Factors of Carbapenem-Resistant Gram-Negative Bacteria Bloodstream Infection in Immunosuppressed Patients: A 7-Year Retrospective Cohort Study.Infection and drug resistance · 2022Article
- Impact of multiple drug-resistant Gram-negative bacterial bacteraemia on infected pancreatic necrosis patients.Frontiers in cellular and infection microbiology · 2022Article
- Epidemiology, antimicrobial resistance, and mortality risk factors of carbapenem resistant gram-negative bacteria in hematopoietic stem cell transplantation recipients.Frontiers in cellular and infection microbiology · 2022Article
- Predictors of mortality in acute pancreatitis complicated with multidrug-resistant Klebsiella pneumoniae infection.BMC infectious diseases · 2021Article
- Emerging of Fatal Colitis with Multidrug-ResistantCase reports in transplantation · 2021Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
introductionCarbapenem-resistant gram-negative bacteria (CR-GNB) can cause life-threatening infections among abdominal solid organ transplantation (ASOT) recipients. This study aimed to investigate the epidemiology and drug susceptibility of CR-GNB pathogens and identity the risk factors associated with 90-day crude mortality of CR-GNB infections among ASOT recipients.
methodsWe retrospectively reviewed the clinical characteristics, drug resistance rate, and risk factors associated with mortality in CR-GNB infections among ASOT recipients between August 1, 2013, and August 1, 2020. The Cox regression model was performed to identify the independent risk factors for mortality.
resultsDuring the 8-year period, CR-GNB infections occurred in 153 of 1452 (10.5%) recipients, and 23 of 153 (15.0%) patients died. The most common pathogen was Acinetobacter baumannii (n = 47). The drug resistance rate of CR-GNB pathogens was relatively low to tigecycline (33.3%) and high to other categories (> 60%). There was a significant increasing trend in drug resistance to tigecycline as time went on (from 24 to 40%, P = 0.04). The independent risk factors for mortality were mechanical ventilation (hazard ratio 7.40, 95% confidence interval 2.69-20.38, P < 0.001), septic shock (hazard ratio 7.41, 95% confidence interval 2.86-19.23, P < 0.001), and platelet count < 50,000/mm
conclusionCR-GNB is widespread with high prevalence and mortality rates among ASOT recipients. Mechanical ventilation, septic shock, and low platelet count represent three independent risk factors related to the mortality of ASOT recipients with CR-GNB infection. We suggest that tigecycline may be used under rigorous management because of the significant increasing risk of drug resistance.
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