Evidence map›Paper›PMID 33611682›Full record

ArticleNeurochemical research2021

Involvement of Protein Kinase A in Oxytocin Neuronal Activity in Rat Dams with Pup Deprivation.

Dongyang Li, Xiaoyu Liu, Tong Li, Xiaoran Wang, Shuwei Jia, Ping Wang, Yu-Feng Wang

Abstract read
PubMed Publisher
In one paragraph

Article in Neurochemical research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
  3. Oxytocin in Women's Health and Disease.Frontiers in endocrinology · 2022
    Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Dongyang Li *Department of Physiology, School of Basic Medical Sciences, Harbin Medical University, Harbin, 150081, China.
Xiaoyu Liu *Department of Physiology, School of Basic Medical Sciences, Harbin Medical University, Harbin, 150081, China.
Tong LiDepartment of Physiology, School of Basic Medical Sciences, Harbin Medical University, Harbin, 150081, China.
Xiaoran WangDepartment of Physiology, School of Basic Medical Sciences, Harbin Medical University, Harbin, 150081, China.
Shuwei JiaDepartment of Physiology, School of Basic Medical Sciences, Harbin Medical University, Harbin, 150081, China.
Ping WangDepartment of Genetics, School of Basic Medical Sciences, Harbin Medical University, Harbin, 150081, China.
Yu-Feng WangDepartment of Physiology, School of Basic Medical Sciences, Harbin Medical University, Harbin, 150081, China. yufengwang@ems.hrbmu.edu.cn.ORCID http://orcid.org/0000-0001-8543-8906
Harbin Medical University · CN

Funding

National Natural Science Foundation of China 31471113
6 · The paper itself

Abstract

Oxytocin (OT) neuronal activity is the key factor for breastfeeding and it can be disrupted by mother-baby separation. To explore cellular mechanisms underlying OT neuronal activity, we studied the role of protein kinase A (PKA) in OT neuronal activity in the supraoptic nucleus (SON) using a rodent model of pup deprivation (PD) Intermittent (IPD) or continuous (CPD) PD significantly reduced suckling duration and number of milk ejections in lactating rats, particularly those with CPD. In Western blots of the SON, PD increased expressions of OT receptor (OTR) and its immediate downstream effectors, Gαq and Gβ subunits, particularly IPD, but reduced the expression of catalytic subunit of PKA (cPKA). In brain slices, inhibition of PKA blocked prostaglandin E

Indexed as

Maternal DeprivationActinsAnimalsCyclic AMP-Dependent Protein Kinase Catalytic SubunitsFemaleLactationMaleNeuronsOxytocinPregnancyRatsRats, Sprague-DawleyReceptors, OxytocinSignal TransductionSupraoptic NucleusActinsCyclic AMP-Dependent Protein Kinase Catalytic SubunitsOxytocinReceptors, OxytocinBreastfeedingMother-newborn separationOxytocin receptorProstaglandinSupraoptic nucleus

Identifiers

PMID33611682
OpenAlexW3129773725

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.