Evidence map›Paper›PMID 33611645›Full record

ArticleSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2021

Failure of Noninvasive Ventilation in Acute Respiratory Failure is Associated with Higher Mortality in Patients with Solid Tumors: A Retrospective Cohort Study.

Francisco Valdez Lima, Ludhmila Abrahão Hajjar, Juliano Pinheiro Almeida, Sergio Ramalho, Gaspar Rogerio Chiappa, Graziella Cipriano, Lawrence Patrick Cahalin, Celso Ricardo de Carvalho, Gerson Cipriano Junior

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Article in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact, top 97% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Francisco Valdez LimaCancer Institute of São Paulo State, São Paulo, Brazil. limasvaldez03@gmail.com.ORCID http://orcid.org/0000-0002-7478-2186
Ludhmila Abrahão HajjarDepartment of Anesthesiology, University of São Paulo, São Paulo, Brazil.
Juliano Pinheiro AlmeidaDepartment of Anesthesiology, University of São Paulo, São Paulo, Brazil.
Sergio RamalhoDepartment of Physical Therapy, University of Brasilia, Brasilia, DF, Brazil.
Gaspar Rogerio ChiappaGraduate Program in Human Movement and Rehabilitation of University Center of Anápolis, Anápolis, Goiânia, GO, Brazil.
Graziella CiprianoDepartment of Physical Therapy, University of Brasilia, Brasilia, DF, Brazil.
Lawrence Patrick CahalinDepartment of Physical Therapy, University of Miami, Coral Gables, FL, USA.
Celso Ricardo de CarvalhoDepartment of Physical Therapy, University of São Paulo, São Paulo, Brazil.
Gerson Cipriano JuniorDepartment of Physical Therapy, University of Brasilia, Brasilia, DF, Brazil.
Universidade de Brasília · BRUniversidade de São Paulo · BRUniversidade Evangelica de Goiás · BRUniversity of Miami · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundNoninvasive Ventilation (NIV) is a well-established treatment for Acute Respiratory Failure (ARF) in hematological cancer. However, the NIV impact on mortality in patients with solid tumors is unclear.

objectiveTo define the factors associated with NIV failure and mortality and to describe the mortality risk of patients with solid tumors requiring NIV for ARF treatment in the intensive care unit (ICU).

methodsA retrospective cohort study of patients with solid tumors admitted into an ICU between Jan 2016 and Dec 2017, for cancer treatment, with ARF diagnosis that had used the NIV as first-line treatment. Our primary outcome was ICU and in-hospital mortality. The secondary outcome was NIV failure. A Cox proportional hazards regression was used to identify variables associated with mortality and NIV failure. Kaplan-Meier analyses were performed to demonstrate cumulative survival.

resultsA total of 226 patients with solid tumors were included. The ICU and hospital mortality rates were 57.5% and 69.5%, respectively. NIV failed in 52.2% of the patients. The use of vasopressors (HR 2.48 [95% CI: 1.43-4.30] p = 0.001), baseline lactate (HR 1.20 [95% CI: 1.07-1.35] p = 0.003), baseline PaO

conclusionsNIV failure was independently associated with an increase in both ICU and hospital mortality rates. In patients with NIV therapy indication, the duration of this intervention was associated with NIV failure.

Indexed as

NeoplasmsNoninvasive VentilationRespiratory Distress SyndromeRespiratory InsufficiencyHospital MortalityHumansIntensive Care UnitsRetrospective StudiesIntensive care unitMortalityNeoplasmsNoninvasive ventilationRespiratory failure

Identifiers

PMID33611645
OpenAlexW3133031230

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.