SynthesisNeurosurgical review2021
A systematic review and meta-analysis of factors affecting the outcome of the epidural blood patching in spontaneous intracranial hypotension.
Synthesis in Neurosurgical review, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.
- Efficacy of Epidural Blood Patching or Surgery in Spontaneous Intracranial Hypotension: A Systematic Review and Evidence Map.AJNR. American journal of neuroradiology · 2023Pooled it
- Predictive factors of epidural blood patch success in intracranial hypotension syndrome.Headache · 2026Article
- Spontaneous epidural blood patch at T2/3 with resolution of intracranial hypotension.Surgical neurology international · 2026Article
- Seizure following epidural blood patch in spontaneous intracranial hypotension complicated by subdural hematoma: Illustrated case and literature review.Surgical neurology international · 2026Article
- Idiopathic CSF dynamic disturbances causing headache: a narrative review.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025Review
- Article
- Epidural blood patch for cerebrospinal fluid leak-induced subdural hematoma in a pediatric patient: illustrative case.Journal of neurosurgery. Case lessons · 2025Article
- Long-Term Headache Outcome and Radiological Correlates in Patients With Intracranial Hypotension.European journal of neurology · 2025Article
- Spontaneous intracranial hypotension occurred during aircraft flight.Acta neurologica Belgica · 2025Article
- Spontaneous Intracranial Hypotension and Dural Ectasia in Marfan Syndrome: An Illustrative Case Successfully Treated with Steroid Therapy and Literature Review.Brain sciences · 2024Article
- Diagnosis and Treatment of Spontaneous Intracranial Hypotension: Role of Epidural Blood Patching.Neurology. Clinical practice · 2024Review
- Acquired tonsillar herniation related to spontaneous intracranial hypotension: case reports.Frontiers in neurology · 2024Article
- Intracranial hypotension in a breast cancer patient treated with epidural blood patches.CNS oncology · 2023Article
- Diagnosis and treatment evaluation in patients with spontaneous intracranial hypotension.Frontiers in neurology · 2023Review
- Spontaneous Intracranial Hypotension: Controversies in Treatment.Acta neurochirurgica. Supplement · 2023Article
- Treating Spontaneous Intracranial Hypotension with an Anesthetic Modality: The Role of the Epidural Blood Patch.Life (Basel, Switzerland) · 2022Article
- Recent update on epidural blood patch.Anesthesia and pain medicine · 2022Review
- Iatrogenic intracranial hypotension secondary to subarachnoid-pleural fistula after transthoracic surgery for the treatment of lateral thoracic meningocele.Journal of craniovertebral junction & spineArticle
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Spontaneous intracranial hypotension (SIH) is an often misdiagnosed condition resulting from non-iatrogenic cerebrospinal fluid (CSF) hypovolemia, typically secondary to spinal CSF leakage. Patients commonly present with posture-related headache, nausea, and vomiting. Following failure of conservative measures, epidural blood patching (EBP) is the most commonly performed intervention for spinal CSF leaks. The authors performed a systematic review and meta-analysis of existing literature to evaluate the role of different factors possibly affecting the efficacy of the EBP procedure. In accordance with the PRISMA guidelines, PubMed/Medline and SCOPUS databases were searched. Six eligible articles were retrieved. Five hundred patients were treated for SIH with EBP, of which 300 reported good response defined as complete remission of symptoms within 48 h after the first EBP requiring no further invasive treatment. Among the factors available for meta-analysis, none was found to be statistically significant in affecting the efficacy of the EBP procedure. A largely symmetrical funnel plot is reported for all the variables evaluated, indicating that publication bias did not play a significant role in the observed effects. The current knowledge about SIH and the EBP is scarce. The existing literature is contradictory and insufficient to aid in clinical practice. More studies are needed to draw significant conclusions that may help in the identification of patients at higher risk of EBP failure, who may benefit from different approaches.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.