SynthesisNeuroradiology2021
Prevalence of brain MRI findings in children with nonacquired growth hormone deficiency: a systematic review and meta-analysis.
Synthesis in Neuroradiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 10 citations in OpenAlex.
- Neuroimaging findings of the hypothalamus and pituitary gland in children with growth hormone deficiency: a 25-year single-center retrospective study.Hormones (Athens, Greece) · 2026Article
- Pituitary magnetic resonance imaging abnormalities and 1-year growth response in children with idiopathic growth hormone deficiency.Annals of pediatric endocrinology & metabolism · 2026Article
- The relationship between pituitary size and the response to recombinant human growth hormone therapy in children with isolated growth hormone deficiency.Frontiers in endocrinology · 2026Article
- Pituitary abnormalities in patients with pediatric growth hormone deficiency in a single tertiary center.Annals of pediatric endocrinology & metabolism · 2024Article
- Dorsoventral splitting of the infundibulum in a child with pituitary hypoplasia.Radiology case reports · 2023Article
- Prevalence of Hypothalamic-Pituitary Abnormalities in Pediatric Patients with Growth Hormone Deficiency.Sage open pediatricsArticle
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo verify and integrate the prevalence and phenotype of abnormalities in the sellar region in patients with growth hormone deficiency (GHD) using MRI data.
methodsWe searched PubMed and EMBASE up to December 14, 2020. The inclusion criteria were as follows: (1) pediatric patients diagnosed with nonacquired GHD and (2) detailed data sufficient to assess the proportion of sellar and parasellar abnormalities on brain MRI scans. Finally, thirty-two studies with 39,060 children (mean or median age, 3.4-14.1 years) were included. The number and type of MRI findings from all included studies were pooled by two authors. The heterogeneity across studies was evaluated with the Q test or the inconsistency index (I
resultsThe pooled proportion of sellar and parasellar abnormalities was 58.0% (95% CI, 47.1-68.6%; I
conclusionThe types and incidence of MRI abnormalities of the sellar region differ significantly between the IGHD and MPHD groups.
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