ArticleJournal of neuropathology and experimental neurology2021
The Second NINDS/NIBIB Consensus Meeting to Define Neuropathological Criteria for the Diagnosis of Chronic Traumatic Encephalopathy.
Article in Journal of neuropathology and experimental neurology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 211 papers, 3 of them syntheses that pooled it.
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Who cites it
211 citing papers in PubMed, 3 syntheses or guidelines pooled it, 304 citations in OpenAlex.
- Cognitive Impairment and Dementia-Related Diagnoses in Chronic Traumatic Encephalopathy: A Systematic Review and Meta-Analysis.Neurology · 2025Pooled it
- Neuropathology in chronic traumatic encephalopathy: a systematic review of comparative post-mortem histology literature.Acta neuropathologica communications · 2022Pooled it
- The prognostic value of neutrophil-to-lymphocyte ratio in patients with traumatic brain injury: A systematic review.Frontiers in neurology · 2022Pooled it
- Mild and repetitive mild traumatic brain injury: Changes in microglial cells and synapses.Neural regeneration research · 2026Article
- Regional ventricular enlargement as an in vivo biomarker of cumulative biomechanical neurodegeneration in former American football players.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Younger Age of First Exposure to American Football Is Associated with Worse Informant-Reported Clinical Outcomes in Older Age Brain Donors.Journal of neurotrauma · 2026Article
- Comparing perceptions of chronic traumatic encephalopathy (CTE) across health care disciplines.PM & R : the journal of injury, function, and rehabilitation · 2026Article
- Neuropsychological Profile of Autopsy-Confirmed Chronic Traumatic Encephalopathy.JAMA network open · 2026Article
- Heterogenous Neuropathology in a Pedigree with RAB39B-Related Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society · 2026Article
- Exploring the neuropathological basis of lateral ventricular enlargement in elderly patients with schizophrenia.Psychiatry and clinical neurosciences · 2026Article
- Cortical subpial aging-related tau astrogliopathy in older adult men who participated in youth amateur American-style football.Journal of neuropathology and experimental neurology · 2026Article
- CTE-type tau filaments in Alzheimer's disease with co-morbid LATE-NC.Acta neuropathologica · 2026Article
- Plasma Phosphorylated Tau 217 in Participants at Risk for Chronic Traumatic Encephalopathy.JAMA network open · 2026Article
- CTE has multiple pathologic variants that might relate to different clinical symptom presentation.Acta neuropathologica · 2026Article
- Brain regional susceptibility to tauopathy in individuals at risk for chronic traumatic encephalopathy.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Spontaneous Isomerization of Tau is Most Prevalent in Alzheimer's Disease.NeuroMarkers · 2026Article
- Performance of traumatic encephalopathy syndrome criteria in identifying individuals with chronic traumatic encephalopathy.Nature medicine · 2026Article
- Commentary: Three questions for the study of traumatic brain injury in animals.Anatomical record (Hoboken, N.J. : 2007) · 2026Article
- Advancing biomarker development for chronic traumatic encephalopathy: Summary and recommendations from the 2025 Leon Thal Summit.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Clinicopathological study of chronic traumatic encephalopathy pathology in a population-based cohort.Journal of neuropathology and experimental neurology · 2026Article
151 more citing papers are in PubMed but not listed here.
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19 authors at 14 institutions in 2 countries.
Funding
Abstract
Chronic traumatic encephalopathy (CTE) is a neurodegenerative disorder associated with exposure to head trauma. In 2015, a panel of neuropathologists funded by the NINDS/NIBIB defined preliminary consensus neuropathological criteria for CTE, including the pathognomonic lesion of CTE as "an accumulation of abnormal hyperphosphorylated tau (p-tau) in neurons and astroglia distributed around small blood vessels at the depths of cortical sulci and in an irregular pattern," based on review of 25 tauopathy cases. In 2016, the consensus panel met again to review and refine the preliminary criteria, with consideration around the minimum threshold for diagnosis and the reproducibility of a proposed pathological staging scheme. Eight neuropathologists evaluated 27 cases of tauopathies (17 CTE cases), blinded to clinical and demographic information. Generalized estimating equation analyses showed a statistically significant association between the raters and CTE diagnosis for both the blinded (OR = 72.11, 95% CI = 19.5-267.0) and unblinded rounds (OR = 256.91, 95% CI = 63.6-1558.6). Based on the challenges in assigning CTE stage, the panel proposed a working protocol including a minimum threshold for CTE diagnosis and an algorithm for the assessment of CTE severity as "Low CTE" or "High CTE" for use in future clinical, pathological, and molecular studies.
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