Evidence map›Paper›PMID 33610745›Full record

ArticleNeuroImage2021

A high-resolution in vivo atlas of the human brain's benzodiazepine binding site of GABA

Martin Nørgaard, Vincent Beliveau, Melanie Ganz, Claus Svarer, Lars H Pinborg, Sune H Keller, Peter S Jensen, Douglas N Greve, Gitte M Knudsen

Open access · goldAbstract read
In one paragraph

Article in NeuroImage, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 90 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
90citing papers in PubMed, 2 pooled it
12.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

90 citing papers in PubMed, 2 syntheses or guidelines pooled it, 140 citations in OpenAlex.

  1. Pooled it
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  7. Effects of diazepam on hippocampal blood flow in people at clinical high risk for psychosis.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024
    Trial
  8. Recovery from disorders of consciousness: Lesions and GABAergic modulation in a biologically inspired spiking neural network.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  9. Building an open infrastructure for molecular neuroimaging: Standards and tools from the OpenNeuroPET initiative.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2026
    Review
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  20. An Interactive Brain Atlas of Knowledge.bioRxiv : the preprint server for biology · 2026
    Article

30 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 3 countries.

Martin NørgaardNeurobiology Research Unit & CIMBI, Copenhagen University Hospital, Rigshospitalet, 2100, Denmark; Institute of Clinical Medicine, University of Copenhagen, Copenhagen, 2100, Denmark.
Vincent BeliveauMedical University of Innsbruck, Department of Neurology, Innsbruck, 6020, Austria.
Melanie GanzNeurobiology Research Unit & CIMBI, Copenhagen University Hospital, Rigshospitalet, 2100, Denmark; University of Copenhagen, Department of Computer Science, Copenhagen, 2100, Denmark.
Claus SvarerNeurobiology Research Unit & CIMBI, Copenhagen University Hospital, Rigshospitalet, 2100, Denmark.
Lars H PinborgNeurobiology Research Unit & CIMBI, Copenhagen University Hospital, Rigshospitalet, 2100, Denmark; Institute of Clinical Medicine, University of Copenhagen, Copenhagen, 2100, Denmark.
Sune H KellerDepartment of Clinical Physiology, Nuclear Medicine and PET, Righospitalet, Copenhagen, 2100, Denmark.
Peter S JensenNeurobiology Research Unit & CIMBI, Copenhagen University Hospital, Rigshospitalet, 2100, Denmark.
Douglas N GreveAthinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02129, United States.
Gitte M KnudsenNeurobiology Research Unit & CIMBI, Copenhagen University Hospital, Rigshospitalet, 2100, Denmark; Institute of Clinical Medicine, University of Copenhagen, Copenhagen, 2100, Denmark. Electronic address: gmk@nru.dk.
University of Copenhagen · DKCopenhagen University Hospital · DKHarvard University · USInnsbruck Medical University · ATRigshospitalet · DK

Funding

FreeSurfer Development, Maintenance, and HardeningR01EB023281 · NIBIB · MASSACHUSETTS GENERAL HOSPITAL · PI Bruce Fischl, Douglas Nowlin Greve · 2016 to 2026
$5.6M
Segmenting Brain Structures for Neurological DisordersR01NS105820 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI Bruce Fischl · 2019 to 2026
$3.2M
NIBIB NIH HHS R01 EB023281NINDS NIH HHS R01 NS105820
6 · The paper itself

Abstract

Gamma-aminobutyric acid (GABA) is the main inhibitory neurotransmitter in the human brain and plays a key role in several brain functions and neuropsychiatric disorders such as anxiety, epilepsy, and depression. For decades, several in vivo and ex vivo techniques have been used to highlight the mechanisms of the GABA system, however, no studies have currently combined the techniques to create a high-resolution multimodal view of the GABA system. Here, we present a quantitative high-resolution in vivo atlas of the human brain benzodiazepine receptor sites (BZR) located on postsynaptic ionotropic GABA

Indexed as

Atlases as TopicAdultAutoradiographyBenzodiazepinesBinding SitesBrainFemaleHumansMaleMiddle AgedPositron-Emission TomographyProtein BindingReceptors, GABA-AYoung AdultBenzodiazepinesReceptors, GABA-AAtlasAutoradiographyBenzodiazepine binding siteGABAmRNAPET

Identifiers

PMID33610745
PMCPMC8256681
OpenAlexW3133173513

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.