ReviewThe Journal of biological chemistry
Amino acid-derived defense metabolites from plants: A potential source to facilitate novel antimicrobial development.
Review in The Journal of biological chemistry. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 73 citations in OpenAlex.
- Application of UPLC-MS/MS-Based Widely Targeted Metabolomics Reveals Metabolic Reprogramming During Post-Harvest Storage ofFoods (Basel, Switzerland) · 2026Article
- Metabolic adaptations of starving purple sea urchins (Strongylocentrotus purpuratus) surviving in the barrens.Scientific reports · 2026Article
- Plant-Derived Peptide-Polymer Therapeutics for Cutaneous Infections and Inflammation: Mechanistic Basis, Delivery Design and Translational Considerations.Pharmaceutics · 2026Review
- Exploring the Health Effects of Phytoestrogens.Metabolites · 2026Review
- Antimicrobial peptides for bacterial infections and their biomedical applications.Discover nano · 2026Review
- Integrative multi-omics analysis reveals stress-specific molecular architectures in soybean under drought and rust infection.BMC genomics · 2026Article
- Tissue-specific amino acid accumulation in Cynomorium songaricum stem and epidermis responds to distinct water and soil cues.PloS one · 2026Article
- Unlocking the therapeutic potential of N-heterocyclic derivatives as Pim kinase inhibitors.Molecular biology reports · 2025Review
- Design and evaluation of a novel pyridine-thiazole hybrid adsorbent as high-capacity adsorbent for methylene blue removal from water.Scientific reports · 2025Article
- Mechanistic and evolutionary insights into a family of aminoacyl-tRNA deacylases that protects against canavanine toxicity.Nucleic acids research · 2025Article
- Article
- Metabolome profiling dissects the oat (Avena sativa L.) innate immune response to Pseudomonas syringae pathovars.PloS one · 2025Article
- CRISPR/dCas12a-mediated activation of SlPAL2 enhances tomato resistance against bacterial canker disease.PloS one · 2025Article
- Metabolomics reveals the effect of vacuum packaging combined with moderate-temperature preservation on quality changes of tender ginger.Food chemistry: X · 2025Article
- Recent Progress in Terrestrial Biota Derived Antibacterial Agents for Medical Applications.Molecules (Basel, Switzerland) · 2024Review
- Metabolome Profiling ofInternational journal of molecular sciences · 2023Article
- Favorable Heteroaromatic Thiazole-Based Polyurea Derivatives as Interesting Biologically Active Products.Polymers · 2023Article
- Novel Arginine- and Proline-Rich Candidacidal Peptides Obtained through a Bioinformatic Approach.Antibiotics (Basel, Switzerland) · 2023Article
- Biosynthesis Investigations of Terpenoid, Alkaloid, and Flavonoid Antimicrobial Agents Derived from Medicinal Plants.Antibiotics (Basel, Switzerland) · 2022Review
- Metabolite Profiling Analysis and the Correlation with Biological Activity of Betalain-RichAntioxidants (Basel, Switzerland) · 2022Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 3 countries.
Funding
Abstract
For millennia, humanity has relied on plants for its medicines, and modern pharmacology continues to reexamine and mine plant metabolites for novel compounds and to guide improvements in biological activity, bioavailability, and chemical stability. The critical problem of antibiotic resistance and increasing exposure to viral and parasitic diseases has spurred renewed interest into drug treatments for infectious diseases. In this context, an urgent revival of natural product discovery is globally underway with special attention directed toward the numerous and chemically diverse plant defensive compounds such as phytoalexins and phytoanticipins that combat herbivores, microbial pathogens, or competing plants. Moreover, advancements in "omics," chemistry, and heterologous expression systems have facilitated the purification and characterization of plant metabolites and the identification of possible therapeutic targets. In this review, we describe several important amino acid-derived classes of plant defensive compounds, including antimicrobial peptides (e.g., defensins, thionins, and knottins), alkaloids, nonproteogenic amino acids, and phenylpropanoids as potential drug leads, examining their mechanisms of action, therapeutic targets, and structure-function relationships. Given their potent antibacterial, antifungal, antiparasitic, and antiviral properties, which can be superior to existing drugs, phytoalexins and phytoanticipins are an excellent resource to facilitate the rational design and development of antimicrobial drugs.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.