Evidence map›Paper›PMID 33610541›Full record

ReviewDevelopmental biology2021

Epigenetic regulation of drosophila germline stem cell maintenance and differentiation.

Velinda Vidaurre, Xin Chen

Open access · greenAbstract readReview
In one paragraph

Review in Developmental biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 23 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. ThebioRxiv : the preprint server for biology · 2024
    Article
  5. Article
  6. Article
  7. Genetic and Epigenetic Regulation ofJournal of developmental biology · 2023
    Review
  8. Article
  9. Article
  10. Cells · 2022
    Article
  11. Article
  12. Mitotic drive in asymmetric epigenetic inheritance.Biochemical Society transactions · 2022
    Article
  13. Review
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Velinda VidaurreDepartment of Biology, The Johns Hopkins University, 3400 North Charles Street, Baltimore, Baltimore, MD, 21218, USA.
Xin ChenDepartment of Biology, The Johns Hopkins University, 3400 North Charles Street, Baltimore, Baltimore, MD, 21218, USA. Electronic address: xchen32@jhu.edu.
Johns Hopkins University · US

Funding

Study epigenetic inheritance during development, homeostasis and regenerationR35GM127075 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI Xin Chen · 2018 to 2026
$3.2M
Epigenetic Regulation of Germ Cell Differentiation from a Stem Cell LineageR01HD102474 · NICHD · JOHNS HOPKINS UNIVERSITY · PI CHEN, XIN · 2020 to 2024
$1.7M
Study mechanisms and biological significance underlying enrichment of Polycomb protein with DNA replication machinery components in Drosophila male germlineF31GM134641 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI VIDAURRE, VELINDA · 2019 to 2021
$137k
Howard Hughes Medical InstituteNICHD NIH HHS R01 HD102474NIGMS NIH HHS F31 GM134641NIGMS NIH HHS R35 GM127075
6 · The paper itself

Abstract

Gametogenesis is one of the most extreme cellular differentiation processes that takes place in Drosophila male and female germlines. This process begins at the germline stem cell, which undergoes asymmetric cell division (ACD) to produce a self-renewed daughter that preserves its stemness and a differentiating daughter cell that undergoes epigenetic and genomic changes to eventually produce haploid gametes. Research in molecular genetics and cellular biology are beginning to take advantage of the continually advancing genomic tools to understand: (1) how germ cells are able to maintain their identity throughout the adult reproductive lifetime, and (2) undergo differentiation in a balanced manner. In this review, we focus on the epigenetic mechanisms that address these two questions through their regulation of germline-soma communication to ensure germline stem cell identity and activity.

Indexed as

Adult Germline Stem CellsAnimalsAsymmetric Cell DivisionCell DifferentiationDrosophilaDrosophila melanogasterDrosophila ProteinsEpigenesis, GeneticEpigenomicsGametogenesisGene ExpressionGene Expression Regulation, DevelopmentalGerm CellsStem CellsDrosophila ProteinsChromatin regulatorDrosophilaEpigeneticsgermline stem cellsSignaling pathwaysSomatic gonadal cellsTranscription

Identifiers

PMID33610541
PMCPMC7992187
OpenAlexW3129349611

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.