ArticleGastroenterology2021
Endoscopic Submucosal Dissection in North America: A Large Prospective Multicenter Study.
Article in Gastroenterology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 92 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Multi-center Prospective Evaluation of the Clinical Utility of Endoscopic Submucosal Dissection (ESD) in the Western Population
Hybrid Versus Non-Hybrid Endoscopic Submucosal Dissection for Colorectal Polyps: A Randomized Trial (SHORT-ESD)
Who cites it
92 citing papers in PubMed, 5 syntheses or guidelines pooled it, 180 citations in OpenAlex.
- The efficacy and safety of traction-assisted endoscopic submucosal resection in early gastric cancer: a systematic review and meta-analysis.Surgical endoscopy · 2026Pooled it
- An Audit of Indications for Endoscopic Submucosal Dissection for Colorectal Lesions in North America: A Systematic Review and Meta-Analysis.Digestive diseases and sciences · 2025Pooled it
- AGA Clinical Practice Guideline on Endoscopic Eradication Therapy of Barrett's Esophagus and Related Neoplasia.Gastroenterology · 2024Guideline
- Recurrence rates after endoscopic resection of large colorectal polyps: A systematic review and meta-analysis.World journal of gastroenterology · 2022Pooled it
- Efficacy of endoscopic mucosal resection versus endoscopic submucosal dissection for rectal neuroendocrine tumors ≤10mm: a systematic review and meta-analysis.Annals of Saudi medicinePooled it
- The Comparison Between Low- and High-Concentration Injection Solution Ability for Colorectal Endoscopic Submucosal Dissection.Journal of gastroenterology and hepatology · 2025Trial
- A Practical Endoscopic Treatment Strategy for Appendiceal Orifice Lesions Using Forceps-Assisted Polypectomy (Strip Biopsy).Digestive diseases and sciences · 2026Article
- Efficacy of endoscopic submucosal dissection for superficial neoplastic lesions in the ileocecal valve region: a large multi-center comparative study.Surgical endoscopy · 2026Article
- Observational
- Flexible endoluminal robotic traction facilitates stable submucosal exposure during endoscopic submucosal dissection.Endoscopy · 2026Article
- Acute Intraoperative Airway Emergency During Submucosal Tunnel Endoscopic Resection for an Esophageal Lesion: A Report of an Unusual Case.The American journal of case reports · 2026Article
- Effect of Prophylactic Colon ESD (Endoscopic Submucosal Dissection) Defect Closure on Post-ESD Outcomes: An International Multi-center Retrospective Study.Digestive diseases and sciences · 2026Article
- Article
- Comparison of Traction and Pocket Creation Methods for Facilitating Colorectal Endoscopic Submucosal Dissection.Digestive diseases and sciences · 2026Article
- Time Prediction Accuracy and Influencing Factors in Colorectal ESD by Trainees: A Mixed-Model Analysis.Digestive diseases and sciences · 2026Article
- Efficacy of endoscopic submucosal dissection in the treatment of early gastrointestinal lesions.World journal of gastrointestinal surgery · 2026Article
- Retrospective comparison of precutting endoscopic band ligation and endoscopic submucosal dissection for small gastric muscularis propria tumors.World journal of gastrointestinal endoscopy · 2026Article
- Predicting the magnitude of risk for non-curative endoscopic submucosal dissection in superficial esophageal cancer using explainable artificial intelligence.World journal of gastrointestinal oncology · 2026Article
- Endoscopic treatment of gastrointestinal perforations and leaks: Why, when, and how?World journal of gastrointestinal endoscopy · 2026Review
- Endoscopic submucosal dissection in gastrointestinal lesions: Clinical outcomes from a single center.Northern clinics of Istanbul · 2026Article
32 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
19 authors at 14 institutions in 2 countries.
Funding
Abstract
BACKGROUND AND
aimsEndoscopic submucosal dissection (ESD) in Asia has been shown to be superior to endoscopic mucosal resection (EMR) and surgery for the management of selected early gastrointestinal cancers. We aimed to evaluate technical outcomes of ESD in North America.
methodsWe conducted a multicenter prospective study on ESD across 10 centers in the United States and Canada between April 2016 and April 2020. End points included rates of en bloc resection, R0 resection, curative resection, adverse events, factors associated with failed resection, and recurrence post-R0 resection.
resultsSix hundred and ninety-two patients (median age, 66 years; 57.8% were men) underwent ESD (median lesion size, 40 mm; interquartile range, 25-52 mm) for lesions in the esophagus (n = 181), stomach (n = 101), duodenum (n = 11), colon (n = 211) and rectum (n = 188). En bloc, R0, and curative resection rates were 91.5%, 84.2%, and 78.3%, respectively. Bleeding and perforation were reported in 2.3% and 2.9% of the cases, respectively. Only 1 patient (0.14%) required surgery for adverse events. On multivariable analysis, severe submucosal fibrosis was associated with failed en bloc, R0, and curative resection and higher risk for adverse events. Overall recurrence was 5.8% (31 of 532) at a mean follow-up of 13.3 months (range, 1-60 months).
conclusionsIn this large multicenter prospective North American experience, we demonstrate that ESD can be performed safely, effectively, and is associated with a low recurrence rate. The technical resection outcomes achieved in this study are in line with the current established consensus quality parameters and further support the implementation of ESD for the treatment of select gastrointestinal neoplasms; ClinicalTrials.gov, Number: NCT02989818.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.