Evidence map›Paper›PMID 33609511›Full record

ReviewExperimental eye research2021

Corneal biomechanics: Measurement and structural correlations.

Jillian Chong, William J Dupps

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Experimental eye research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed, 4 pooled it
6.5field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 4 syntheses or guidelines pooled it, 71 citations in OpenAlex.

  1. Corneal biomechanical changes in patients with anterior chamber inflammation: a systematic review and meta-analysis.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2025
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  5. Intraocular pressure and corneal biomechanics in patients affected by myotonic dystrophy type 1.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026
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  10. Intraocular pressure measurement in keratoconus: a narrative review.International journal of ophthalmology · 2026
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Jillian ChongCleveland Clinic Cole Eye Institute, Cleveland Clinic, Cleveland, OH, USA.
William J DuppsCleveland Clinic Cole Eye Institute, Cleveland Clinic, Cleveland, OH, USA; Dept. of Ophthalmology, Cleveland Clinic Lerner College of Medicine of Case Western Reserve Univ, Cleveland, OH, USA; Dept. of Biomedical Engineering, Lerner Research Institute and Case Western Reserve Univ, Cleveland, OH, USA. Electronic address: duppsw@ccf.org.
Cleveland Clinic · US

Funding

RESOURCE/SERVICE CORE C - MOLECULAR INFORMATICS MODULEP30EY025585 · NEI · CLEVELAND CLINIC LERNER COM-CWRU · PI BELA ANAND-APTE · 2016 to 2026
$7.7M
Corneal Elastography and Patient-Specific Modeling for Simulation-based TherapyR01EY023381 · NEI · CLEVELAND CLINIC LERNER COM-CWRU · PI DUPPS, WILLIAM JOSEPH · 2013 to 2017
$2.0M
Noninvasive assessment of the cornea by diffusion OCTR01EY028667 · NEI · CASE WESTERN RESERVE UNIVERSITY · PI DUPPS, WILLIAM JOSEPH, ROLLINS, ANDREW MARTIN · 2018 to 2022
$2.0M
NEI NIH HHS P30 EY025585NEI NIH HHS R01 EY023381NEI NIH HHS R01 EY028667
6 · The paper itself

Abstract

The characterization of corneal biomechanical properties has important implications for the management of ocular disease and prediction of surgical responses. Corneal refractive surgery outcomes, progression or stabilization of ectatic disease, and intraocular pressure determination are just examples of the many key clinical problems that depend highly upon corneal biomechanical characteristics. However, to date there is no gold standard measurement technique. Since the advent of a 1-dimensional (1D) air-puff based technique for measuring the corneal surface response in 2005, advances in clinical imaging technology have yielded increasingly sophisticated approaches to characterizing the biomechanical properties of the cornea. Novel analyses of 1D responses are expanding the clinical utility of commercially-available air-puff-based instruments, and other imaging modalities-including optical coherence elastography (OCE), Brillouin microscopy and phase-decorrelation ocular coherence tomography (PhD-OCT)-offer new opportunities for probing local biomechanical behavior in 3-dimensional space and drawing new inferences about the relationships between corneal structure, mechanical behavior, and corneal refractive function. These advances are likely to drive greater clinical adoption of in vivo biomechanical analysis and to support more personalized medical and surgical decision-making.

Indexed as

Biomechanical PhenomenaCorneaElasticityElasticity Imaging TechniquesHumansImaging, Three-DimensionalMicroscopyTomography, Optical CoherenceBrillouin microscopyCorneal biomechanicsCorneal hysteresisCorvis STOcular coherence elastographyOcular response analyzer

Identifiers

PMID33609511
PMCPMC8046161
OpenAlexW3129707213

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.