Evidence map›Paper›PMID 33609419›Full record

ArticleCancer communications (London, England)2021

Impact of diabetes on promoting the growth of breast cancer.

Ping-Chieh Chou, Hyun Ho Choi, Yizhi Huang, Enrique Fuentes-Mattei, Guermarie Velazquez-Torres, Fanmao Zhang, Liem Phan, Jaehyuk Lee, Yanxia Shi, James A Bankson and 5 more

Open access · goldAbstract read
In one paragraph

Article in Cancer communications (London, England), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 34 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 2 institutions in 2 countries.

Ping-Chieh ChouDepartment of Molecular and Cellular Oncology, the University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.
Hyun Ho ChoiGuangdong Provincial Key laboratory of Colorectal and Pelvic Floor Disease, the Sixth Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, 510020, P. R. China.
Yizhi HuangGuangdong Provincial Key laboratory of Colorectal and Pelvic Floor Disease, the Sixth Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, 510020, P. R. China.
Enrique Fuentes-MatteiDepartment of Molecular and Cellular Oncology, the University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.
Guermarie Velazquez-TorresDepartment of Molecular and Cellular Oncology, the University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.
Fanmao ZhangDepartment of Molecular and Cellular Oncology, the University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.
Liem PhanDepartment of Molecular and Cellular Oncology, the University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.
Jaehyuk LeeDepartment of Imaging Physics, the University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.
Yanxia ShiDepartment of Medical Oncology, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, 510060, P. R. China.ORCID 0000-0002-5414-8049
James A BanksonDepartment of Imaging Physics, the University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.
Yun WuDepartment of Pathology, the University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.
Huamin WangDepartment of Pathology, the University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.
Ruiying ZhaoDepartment of Molecular and Cellular Oncology, the University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.
Sai-Ching Jim YeungDepartment of Emergency Medicine, the University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.
Mong-Hong LeeDepartment of Molecular and Cellular Oncology, the University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.ORCID 0000-0001-8675-8215
The University of Texas MD Anderson Cancer Center · USSun Yat-sen University · CN

Funding

Fidelity Foundation 2020YFA0803300National Natural Science Foundation of China 8160242National Natural Science Foundation of China 81630072National Natural Science Foundation of China 81702749National Natural Science Foundation of China 81773098National Natural Science Foundation of China 81803568Shenzhen Municipal Government
6 · The paper itself

Abstract

backgroundType II diabetes mellitus (DM2) is a significant risk factor for cancers, including breast cancer. However, a proper diabetic breast cancer mouse model is not well-established for treatment strategy design. Additionally, the precise diabetic signaling pathways that regulate cancer growth remain unresolved. In the present study, we established a suitable mouse model and demonstrated the pathogenic role of diabetes on breast cancer progression.

methodsWe successfully generated a transgenic mouse model of human epidermal growth factor receptor 2 positive (Her2

resultsTreatment with metformin/rosiglitazone in MMTV-ErbB2/Lepr

conclusionsMMTV-ErbB2/Lepr

Indexed as

Breast NeoplasmsDiabetes Mellitus, Type 2AnimalsDisease Models, AnimalFemaleHumansMiceMice, TransgenicSignal Transductionbreast cancerdiabeteshuman epidermal growth factor receptor 2metabolismmetformin

Identifiers

PMID33609419
PMCPMC8118590
OpenAlexW3129958206

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.