ArticleBJS open2021
Autofluorescence pattern of parathyroid adenomas.
Article in BJS open, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.
- Near-infrared autofluorescence-based parathyroid glands identification in the thyroidectomy or parathyroidectomy: a systematic review and meta-analysis.Langenbeck's archives of surgery · 2022Pooled it
- Assessment of PTeye™ versus FLUOBEAM® LX for parathyroid adenomas: a pilot case-control study.Updates in surgery · 2025Trial
- Parathyroid histology in normocalcemic and hypercalcemic primary hyperparathyroidism with hypercalciuric renal stones.Journal of the Endocrine Society · 2026Article
- Autofluorescence Imaging of Parathyroid and Thyroid Under Visible and Near-IR Light Excitation.Biosensors · 2025Article
- Article
- Near-infrared autofluorescence pattern in parathyroid gland adenoma.Surgical endoscopy · 2024Article
- Advancing parathyroid surgery: a critical examination of probe-based near-infrared autofluorescence technology.Gland surgery · 2024Article
- Silicon-Rhodamine Functionalized Evocalcet Probes Potently and Selectively Label Calcium Sensing ReceptorsACS pharmacology & translational science · 2024Article
- Feasibility of Autofluorescence Using Overlay Imaging for the Detection of Parathyroid Glands: Defining Standards.Annals of surgical oncology · 2024Article
- Editorial: 2023 symposium on parathyroid fluorescence.Frontiers in endocrinology · 2024Article
- Converting a probe-based fluorescence system into an easy-to-use adjunct for the detection of parathyroid glands accidentally resected intraoperatively.Langenbeck's archives of surgery · 2023Article
- Resection of ectopic parathyroid adenomas within the carotid sheath-can fluorescence help the surgeon?Gland surgery · 2023Article
- Why does diseased parathyroid appear weak or heterogenous intensity during intraoperative near-infrared autofluorescence?Frontiers in endocrinology · 2023Article
- The magic mirror: a novel intraoperative monitoring method for parathyroid glands.Frontiers in endocrinology · 2023Review
- Near-infrared fluorescent imaging techniques for the detection and preservation of parathyroid glands during endocrine surgery.Innovative surgical sciences · 2022Article
- A coaxial excitation, dual-red-green-blue/near-infrared paired imaging system toward computer-aided detection of parathyroid glands in situ and ex vivo.Journal of biophotonics · 2022Article
- A pilot feasibility study to assess vascularity and perfusion of parathyroid glands using a portable hand-held imager.Lasers in surgery and medicine · 2022Article
- Preliminary experience with the EleVision IR system in detection of parathyroid glands autofluorescence and perfusion assessment with ICG.Frontiers in endocrinology · 2022Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPrimary hyperparathyroidism (pHPT) is a common endocrine pathology, and it is due to a single parathyroid adenoma in 80-85 per cent of patients. Near-infrared autofluorescence (NIRAF) has recently been used in endocrine surgery to help in the identification of parathyroid tissue, although there is currently no consensus on whether this technique can differentiate between normal and abnormal parathyroid glands. The aim of this study was to describe the autofluorescence pattern of parathyroid adenoma in pHPT.
methodsBetween January and June 2019, patients with pHPT who underwent surgical treatment for parathyroid adenoma were enrolled. Parathyroid autofluorescence was measured.
resultsTwenty-three patients with histologically confirmed parathyroid adenomas were included. Parathyroid adenomas showed a heterogeneous fluorescence pattern, and a well defined autofluorescent 'cap' region was observed in 17 of 23 specimens. This region was on average 28 per cent more fluorescent than the rest of the adenoma, and corresponded to a rim of normal histological parathyroid tissue (sensitivity and specificity 88 and 67 per cent respectively). After resection, all patients were treated successfully, with normal postoperative values of calcium and parathyroid hormone documented.
conclusionParathyroid adenomas show a heterogeneous autofluorescence pattern. Using NIRAF imaging, the majority of specimens showed a well defined autofluorescent portion corresponding to a rim of normal parathyroid tissue. Further studies should be conducted to validate these findings.
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