SynthesisBJS open2021
Association of intraoperative hypotension with postoperative morbidity and mortality: systematic review and meta-analysis.
Synthesis in BJS open, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 52 papers, 7 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Artificial Intelligence - to Predict and Prevent Hypotension During Surgery
Prospective Validation of Intraoperative Blood Pressure Monitors: the Influence of Site and Execution Strategy. The PROMISES Trial
Who cites it
52 citing papers in PubMed, 7 syntheses or guidelines pooled it, 114 citations in OpenAlex.
- Intraoperative hypotension and postoperative risks in non-cardiac surgery: a meta-analysis.BMC anesthesiology · 2025Pooled it
- The effect of intraoperative hypotension on postoperative delirium: a meta-analysis and systematic review.Frontiers in medicine · 2025Pooled it
- Machine learning-augmented interventions in perioperative care: a systematic review and meta-analysis.British journal of anaesthesia · 2024Pooled it
- Predictive ability of hypotension prediction index and machine learning methods in intraoperative hypotension: a systematic review and meta-analysis.Journal of translational medicine · 2024Pooled it
- Dexmedetomidine versus remifentanil in nasal surgery: a systematic review and meta-analysis.BMC anesthesiology · 2024Pooled it
- Hypotension during intensive care stay and mortality and morbidity: a systematic review and meta-analysis.Intensive care medicine · 2024Pooled it
- Morbidity and mortality in patients managed with high compared with low blood pressure targets during on-pump cardiac surgery: a systematic review and meta-analysis of randomized controlled trials.Canadian journal of anaesthesia = Journal canadien d'anesthesie · 2022Pooled it
- Esketamine attenuates hemodynamic oscillations during anesthesia induction in elderly gastrointestinal surgical patients: a randomized trial.BMC anesthesiology · 2025Trial
- Hip Fracture Intervention Study for Prevention of Hypotension Trial: a Pilot Randomized Controlled Trial.A&A practice · 2025Trial
- Comparison of different ratios of propofol-ketamine admixture in rapid-sequence induction of anesthesia for emergency laparotomy: a randomized controlled trial.BMC anesthesiology · 2023Trial
- Learning curve of blood pressure management during phaeochromocytoma surgery without preoperative alpha-blockade dose escalation.Endocrine connections · 2026Article
- Automated alerts and intraoperative noninvasive blood pressure monitoring gaps: a retrospective before-and-after study.BMC anesthesiology · 2026Article
- Article
- Intraoperative Hypotension in Children Undergoing Noncardiac Surgery: An Exploratory Single-Center Analysis of Incidence, Associated Risk Factors, and Outcomes.Anesthesia and analgesia · 2026Article
- Intraoperative blood pressure management in noncardiac surgery: a narrative review based on current evidence.Intensive care medicine · 2026Review
- Clinical implications and feasibility of cerebral autoregulation-based precision blood pressure monitoring in major noncardiac surgery: A protocol for AUTOREGULATE-NONCARDIAC, a multicentre prospective cohort study and peri-operative precision medicine platform.European journal of anaesthesiology and intensive care · 2026Article
- Article
- Association between cumulative intraoperative hypotension and postoperative ICU admission after gastrointestinal lumen cancer surgery: a retrospective cohort study using the INSPIRE database.Frontiers in medicine · 2026Article
- Intraoperative Hypotension and Delayed Graft Function after Kidney Transplantation: A Retrospective Cohort Analysis.Anesthesiology open · 2026Article
- Comparison of intraoperative hemodynamic parameters between propofol- and remimazolam-based total intravenous anesthesia in patients undergoing robotic gynecologic surgery: a randomized controlled trial protocol.Frontiers in pharmacology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIntraoperative hypotension, with varying definitions in literature, may be associated with postoperative complications. The aim of this meta-analysis was to assess the association of intraoperative hypotension with postoperative morbidity and mortality.
methodsMEDLINE, Embase and Cochrane databases were searched for studies published between January 1990 and August 2018. The primary endpoints were postoperative overall morbidity and mortality. Secondary endpoints were postoperative cardiac outcomes, acute kidney injury, stroke, delirium, surgical outcomes and combined outcomes. Subgroup analyses, sensitivity analyses and a meta-regression were performed to test the robustness of the results and to explore heterogeneity.
resultsThe search identified 2931 studies, of which 29 were included in the meta-analysis, consisting of 130 862 patients. Intraoperative hypotension was associated with an increased risk of morbidity (odds ratio (OR) 2.08, 95 per cent confidence interval 1.56 to 2.77) and mortality (OR 1.94, 1.32 to 2.84). In the secondary analyses, intraoperative hypotension was associated with cardiac complications (OR 2.44, 1.52 to 3.93) and acute kidney injury (OR 2.69, 1.31 to 5.55). Overall heterogeneity was high, with an I2 value of 88 per cent. When hypotension severity, outcome severity and study population variables were added to the meta-regression, heterogeneity was reduced to 50 per cent.
conclusionIntraoperative hypotension during non-cardiac surgery is associated with postoperative cardiac and renal morbidity, and mortality. A universally accepted standard definition of hypotension would facilitate further research into this topic.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.