Evidence map›Paper›PMID 33609216›Full record

ArticleMarine biotechnology (New York, N.Y.)2021

Genome-Wide Association Analysis Reveals the Genetic Architecture of Parasite (Cryptocaryon irritans) Resistance in Large Yellow Croaker (Larimichthys crocea).

Ji Zhao, Tao Zhou, Huaqiang Bai, Qiaozhen Ke, Bijun Li, Mindong Bai, Zhixiong Zhou, Fei Pu, Weiqiang Zheng, Peng Xu

Abstract read
PubMed Publisher
In one paragraph

Article in Marine biotechnology (New York, N.Y.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 42 citations in OpenAlex.

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  7. pH Regulates the Formation and Hatching ofApplied and environmental microbiology · 2022
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  8. The Draft Genome ofFrontiers in genetics · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Ji Zhao *State Key Laboratory of Marine Environmental Science, College of Ocean and Earth Sciences, Xiamen University, Xiamen, China.
Tao Zhou *Fujian Key Laboratory of Genetics and Breeding of Marine Organisms, College of Ocean and Earth Sciences, Xiamen University, Xiamen, China.
Huaqiang BaiFujian Key Laboratory of Genetics and Breeding of Marine Organisms, College of Ocean and Earth Sciences, Xiamen University, Xiamen, China.
Qiaozhen KeFujian Key Laboratory of Genetics and Breeding of Marine Organisms, College of Ocean and Earth Sciences, Xiamen University, Xiamen, China.
Bijun LiFujian Key Laboratory of Genetics and Breeding of Marine Organisms, College of Ocean and Earth Sciences, Xiamen University, Xiamen, China.
Mindong BaiKey Laboratory of the Ministry of Education for Coastal and Wetland Ecosystems, College of the Environment and Ecology, Xiamen University, Xiamen, China.
Zhixiong ZhouFujian Key Laboratory of Genetics and Breeding of Marine Organisms, College of Ocean and Earth Sciences, Xiamen University, Xiamen, China.
Fei PuFujian Key Laboratory of Genetics and Breeding of Marine Organisms, College of Ocean and Earth Sciences, Xiamen University, Xiamen, China.
Weiqiang ZhengState Key Laboratory of Large Yellow Croaker Breeding, Ningde Fufa Fisheries Company Limited, Ningde, China.
Peng XuState Key Laboratory of Marine Environmental Science, College of Ocean and Earth Sciences, Xiamen University, Xiamen, China. xupeng77@xmu.edu.cn.ORCID http://orcid.org/0000-0002-1531-5078
Xiamen University · CN

Funding

Independent Research Project for State Key Laboratory of Large Yellow Croaker Breeding LYC2017ZY01Industry-University Collaboration Project of Fujian Province 2019N5001Open Research Fund Project of State Key Laboratory of Large Yellow Croaker Breeding LYC2019RS02 and LYC2019RS03Science and Technology Major Project of Fujian Province 2020NZ08003the Foreign Cooperation Project of Fujian Province No.2019I1008the Fundamental Research Funds for the Central Universities No. 20720200110the National Key Research and Development Program of China 2018YFC1406306the Project of Industry-College-Institute Cooperation between Ningde City and Xiamen University No. 2019C002the Special Project of Local Science and Technology Development Guided by the Central Government 2019L3032
6 · The paper itself

Abstract

Large yellow croaker is an important marine culture species in China. Recently, the large yellow croaker industry is threatened by various disease problems, especially for the white spot disease, which is caused by parasite Cryptocaryon irritans. In the current study, we conducted a genome-wide association study (GWAS) for C. irritans resistance in two large yellow croaker populations (n = 264 and n = 480, respectively). We identified 15 QTL with explained genetic variance ranging from 1 to 8% in the two populations. One QTL on chromosome 23 was shared by the two populations, and three QTL had been reported in the previous study. We identified a lot of biological pathways associated with C. irritans resistance, such as hormone transport, response to bacterium, apoptotic process, acute inflammatory response to antigenic stimulus, and NF-kappa B signaling pathway. The genes casp8 and traf6 involved in regulatory network for apoptosis and inflammation were identified to be candidate genes for C. irritans resistance. Our results showed the complex polygenic architecture of resistance of large yellow croaker against C. irritans. These results would be helpful for the researches of the molecular mechanism of C. irritans resistance and genome-assisted breeding of large yellow croaker.

Indexed as

AnimalsApoptosisAquacultureCiliophoraCiliophora InfectionsDisease ResistanceFish DiseasesGenome-Wide Association StudyInflammationPerciformesQuantitative Trait LociSignal TransductionC. irritansDisease resistanceGenetic architectureGWASOntology

Identifiers

PMID33609216
OpenAlexW3130263542

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.