SynthesisInternational ophthalmology2021
Femtosecond laser-assisted stromal keratophakia for keratoconus: A systemic review and meta-analysis.
Synthesis in International ophthalmology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 41 citations in OpenAlex.
- Biomechanical changes in keratoconus after customized stromal augmentation.Taiwan journal of ophthalmologyTrial
- Preservation and Reuse of KLEx Lenticules: From Biobanking to Therapeutic and Refractive Innovations.Bioengineering (Basel, Switzerland) · 2026Review
- Paediatric Keratoconus: An ERN-EYE Clinical Consensus Statement on Diagnosis, Treatment and Follow-Up Care.Ophthalmology and therapy · 2026Review
- Ex Vivo Assessment of Excimer Laser-Assisted Lenticule Customization.Translational vision science & technology · 2026Article
- Feasibility Study of Decellularized Corneal Lenticule in a Porcine Model for Macular Hole Closure.Ophthalmology and therapy · 2026Article
- [New tissue-additive procedures to improve vision in keratoconus].Die Ophthalmologie · 2026Review
- Femtosecond Laser-Assisted Keratoplasty: A Narrative Review of Technological Evolution, Clinical Evidence, Implementation and Future Directions.Clinical ophthalmology (Auckland, N.Z.) · 2026Review
- Advancements and Innovations in Keratoconus Management: A Review of Current Practices.Journal of clinical medicine · 2025Review
- Combined femtosecond intrastromal lenticular implantation and corneal crosslinking to treat advanced keratoconus: a 6-month observation including epithelial remodeling.BMC ophthalmology · 2025Article
- The Preservation and Reuse of Lenticules Extracted via Small Incision Lenticule Extraction (SMILE): A Narrative Review.Bioengineering (Basel, Switzerland) · 2025Review
- Enhanced Riboflavin Stromal Delivery Using Microchannel-Assisted Iontophoresis for Corneal Crosslinking.Translational vision science & technology · 2025Article
- Comparing the Efficacy and Safety of Femtosecond Laser-Enabled Keratoplasty and Conventional Penetrating Keratoplasty: A Systematic Review and Meta-Analysis.Clinical ophthalmology (Auckland, N.Z.) · 2025Review
- Topographic factors associated with anterior chamber angle narrowing in patients with keratoconus.International journal of ophthalmology · 2025Article
- Corneal surface changes after stromal lenticule addition keratoplasty combined with cross-linking for severe keratoconus.International journal of ophthalmology · 2025Article
- Banking of post-SMILE stromal lenticules for additive keratoplasty: A new challenge for eye banks?International ophthalmology · 2024Review
- Ex Vivo Lenticule Customization for Stromal Lenticule Addition Keratoplasty.Investigative ophthalmology & visual science · 2024Article
- Applications of SMILE-extracted lenticules in ophthalmology.International journal of ophthalmology · 2024Review
- Opportunities for Improving the Long-term Management of Keratoconus Patients.Journal of contact lens research & science · 2024Article
- Customized corneal allogenic intrastromal ring segments (CAIRS) for keratoconus with decentered asymmetric cone.Indian journal of ophthalmology · 2023Article
- Management of keratoconus: an updated review.Frontiers in medicine · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 4 institutions in 3 countries.
Funding
Abstract
purposeFemtosecond lasers have revived the possibility of stromal keratophakia or tissue additive keratoplasty, a technique originally introduced by Prof. Jose Ignacio Barraquer in the 1960s. The surgical technique offers a unique solution to treat keratoconus. In the current study, we reviewed and performed a meta-analysis of the clinical outcomes of the femtosecond laser-assisted stromal keratophakia in the treatment of keratoconus.
methodsThis is a systematic review and meta-analysis of the estimated outcome difference between pre- and post-lenticule implantations.
resultsA total of related 10 studies were found in the literature. No studies reported adverse events, such as persistent haze or graft rejection, at last patients' visits. We further narrowed down the article selection in accordance to our inclusion criteria to report the composite outcomes (9 studies) and meta-analysis (4 studies). In the composite analysis, we demonstrated that lenticule implantation in keratoconus and post-LASIK ectasia patients appeared to expand the stromal volume of the thin corneas, flattened the cones, and significantly improved uncorrected visual acuity (UCVA), best-corrected visual acuity (BCVA) and spherical equivalent (SE). The meta-analysis showed that the random estimated UCVA, BCVA, SE and mean keratometry (K
conclusionsFemtosecond laser-assisted stromal keratophakia is a feasible technique to correct the refractive aberrations, expand corneal volume and regularize corneal curvature in patients with keratoconus. However, there is a need to standardize the technique (e.g., whether to crosslink or not or to use convex or concave lenticules) and to formulate a mathematical model that accounts for the long-term epithelial thickness changes and stromal remodeling to determine the shape or profile of the lenticules, in order to improve the efficacy of the keratophakia further.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.