Evidence map›Paper›PMID 33609186›Full record

SynthesisClinical oral investigations2021

Use of platelet-rich fibrin for the treatment of periodontal intrabony defects: a systematic review and meta-analysis.

Richard J Miron, Vittorio Moraschini, Masako Fujioka-Kobayashi, Yufeng Zhang, Tomoyuki Kawase, Raluca Cosgarea, Soren Jepsen, Mark Bishara, Luigi Canullo, Yoshinori Shirakata and 5 more

2 registry-linked trialsOpen access · hybridAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Clinical oral investigations, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 91 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
91citing papers in PubMed, 7 pooled it
28.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06768424 narecruitingnot on this mapstarted 2023, after this paper: background citation

Comparison of Minimally Invasive Surgical Therapy in Combination With Platelet Rich Fibrine and Guided Biofilm Therapy Combined With Platelet Rich Fibrine in the Treatment of Solitaire Intrabony Periodontal Defect A Prospective RCT.

TypeinterventionalSponsorSemmelweis UniversityRan2023 to 2027Enrolled36ConditionsIntrabony Periodontal DefectArmsGuided biofilm therapy, Platelet Rich Fibrin, Minimally Invasive Surgical Technique
NCT06776289 phase4not yet recruitingnot on this mapstarted 2026, after this paper: background citation

Endodontic Microsurgery With and Without Platelet-Rich Fibrin

TypeinterventionalSponsorMark SchachmanRan2026 to 2027Enrolled20ConditionsApical PeriodontitisArmsPlatelet rich fibrin
3 · Its place in the literature

Who cites it

91 citing papers in PubMed, 7 syntheses or guidelines pooled it, 168 citations in OpenAlex.

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31 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 10 institutions in 9 countries.

Richard J Miron *Department of Periodontology, University of Bern, Bern, Switzerland. richard.miron@zmk.unibe.ch.ORCID http://orcid.org/0000-0003-3290-3418
Vittorio Moraschini *Department of Periodontology, Dental Research Division, School of Dentistry, Veiga de Almeida University, Rio de Janeiro, Brazil.
Masako Fujioka-KobayashiDepartment of Cranio-Maxillofacial Surgery, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Yufeng ZhangDepartment of Oral Implantology, University of Wuhan, Wuhan, China.
Tomoyuki KawaseDivision of Oral Bioengineering, Institute of Medicine and Dentistry, Niigata University, Niigata, Japan.
Raluca CosgareaDepartment of Prosthetic Dentistry, University Iuliu Hatieganu, Cluj-Napoca, Romania.
Soren JepsenDepartment of Periodontology, Operative and Preventive Dentistry, University of Bonn, Bonn, Germany.
Mark BisharaDivision Private practice, West Bowmanville Family Dental, Bowmanville, Ontario, Canada.
Luigi CanulloIndependent researcher, Rome, Italy.
Yoshinori ShirakataDepartment of Periodontology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.
Reinhard GruberDepartment of Oral Biology, University of Vienna, Vienna, Austria.
Döri FerencDepartment of Periodontology, Semmelweis University, Budapest, Hungary.
Monica Diuana Calasans-MaiaDepartment of Oral Surgery, School of Dentistry, Fluminense Federal University, Rua Mario dos Santos Braga, 30, Centro, Niteroi, Rio de Janeiro, Brazil.
Hom-Lay WangDepartment of Periodontology, University of Bern, Bern, Switzerland.
Anton SculeanDepartment of Periodontology, University of Bern, Bern, Switzerland.
University of Bern · CHIuliu Hațieganu University of Medicine and Pharmacy · ROKagoshima University · JPNiigata University · JPSemmelweis University · HUUniversidade Federal Fluminense · BRUniversidade Veiga de Almeida · BRUniversity of Bonn · DEUniversity of Vienna · ATWuhan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesThis study aims to compare the treatment outcomes of periodontal intrabony defects by using platelet-rich fibrin (PRF) with other commonly utilized modalities. MATERIALS AND

methodsThe eligibility criteria comprised randomized controlled trials (RCTs) comparing the clinical outcomes of PRF with that of other modalities. Studies were classified into 10 categories as follows: (1) open flap debridement (OFD) alone versus OFD/PRF; (2) OFD/bone graft (OFD/BG) versus OFD/PRF; (3) OFD/BG versus OFD/BG/PRF; (4-6) OFD/barrier membrane (BM), OFD/PRP, or OFD/enamel matrix derivative (EMD) versus OFD/PRF; (7) OFD/EMD versus OFD/EMD/PRF; (8-10) OFD/PRF versus OFD/PRF/metformin, OFD/PRF/bisphosphonates, or OFD/PRF/statins. Weighted means and forest plots were calculated for probing depth (PD), clinical attachment level (CAL), and radiographic bone fill (RBF).

resultsFrom 551 articles identified, 27 RCTs were included. The use of OFD/PRF statistically significantly reduced PD and improved CAL and RBF when compared to OFD. No clinically significant differences were reported when OFD/BG was compared to OFD/PRF. The addition of PRF to OFD/BG led to significant improvements in CAL and RBF. No differences were reported between any of the following groups (OFD/BM, OFD/PRP, and OFD/EMD) when compared to OFD/PRF. No improvements were also reported when PRF was added to OFD/EMD. The addition of all three of the following biomolecules (metformin, bisphosphonates, and statins) to OFD/PRF led to statistically significant improvements of PD, CAL, and RBF.

conclusionsThe use of PRF significantly improved clinical outcomes in intrabony defects when compared to OFD alone with similar levels being observed between OFD/BG and OFD/PRF. Future research geared toward better understanding potential ways to enhance the regenerative properties of PRF with various small biomolecules may prove valuable for future clinical applications. Future research investigating PRF at histological level is also needed. CLINICAL RELEVANCE: The use of PRF in conjunction with OFD statistically significantly improved PD, CAL, and RBF values, yielding to comparable outcomes to OFD/BG. The combination of PRF with bone grafts or small biomolecules may offer certain clinical advantages, thus warranting further investigations.

Indexed as

Alveolar Bone LossPlatelet-Rich FibrinBone TransplantationGuided Tissue Regeneration, PeriodontalHumansPeriodontal Attachment LossSurgical FlapsAdvanced-PRFIntrabony defectL-PRFPlatelet-rich fibrin

Identifiers

PMID33609186
PMCPMC8060184
OpenAlexW3131840634

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.